The structure and pharmacological properties of the 4-acetoxy-1-(2-ethoxyethyl)-4-phenylpiperidine inclusion complex with β-cyclodextrin

  • R. A. Sharipov
  • K. S. Sharapov
  • U. S. Kemelbekov
  • V. A. VolynkinEmail author
  • V. K. Yu
  • V. T. Panyushkin
  • K. D. Praliev
Original Article


Inclusion complex of 4-acetoxy-1-(2-ethoxyethyl)-4-phenylpiperidine with β-cyclodextrin was synthesized. Composition (1:2) and the structure of the complex were confirmed by NMR spectroscopy and thermal analysis. The results of pharmacological studies showed that the compound is of interest for in-depth testing, because of its deeper and more prolonged conduction anaesthesia, terminal (superficial) and infiltration anaesthesia along with less acute toxicity compared to the reference preparations.


Cyclodextrin Anaesthetic Pharmacological properties ROESY 


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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  1. 1.Kokshetau Technical Institute of the Kazakhstan Ministry of Emergency SituationsKokshetauKazakhstan
  2. 2.Kuban State UniversityKrasnodarRussia
  3. 3.National Centre for Expertise of Medicines, Medical Devices and Medical EquipmentAlmatyKazakhstan
  4. 4.A.B. Bekturov Institute of Chemical SciencesAlmatyKazakhstan

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