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Complexation of sodium picosulphate with beta cyclodextrin: NMR spectroscopic study in solution

  • Arti MaheshwariEmail author
  • Manisha Sharma
  • Deepak Sharma
Original Article

Abstract

Sodium Picosulphate (SPL) is a synthetic drug, widely used for thorough evacuation of the bowel, usually for patients who are preparing to undergo a colonoscopy. Cyclodextrins (CDs) are chiral, truncated cone shaped, cyclic oligosaccharides that can encapsulate a variety of drug molecules into inclusion complexes, thereby increasing their stability and solubility. 1H NMR spectroscopic studies showed the inclusion complexation between β-CD and SPL, based on the upfield shift changes in the β-CD cavity protons (H-3′ and H-5′) and downfield shift changes in the guest (SPL) protons. The structure of inclusion complexes was determined by 2D ROESY spectral data. The 1:1 stoichiometry and overall association constant (Ka) were determined by using Scott’s plot method to be 450 M−1.

Keywords

Sodium picosulphate β-Cyclodextrin ROESY COSY NMR Inclusion complex 

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Arti Maheshwari
    • 1
    Email author
  • Manisha Sharma
    • 1
  • Deepak Sharma
    • 2
  1. 1.Department of ChemistryMangalayatan UniversityAligarhIndia
  2. 2.Department of PhysicsMangalayatan UniversityAligarhIndia

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