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Drug/cyclodextrin: beyond inclusion complexation

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Abstract

Development of cyclodextrins as enabling excipients began decades ago and during this time a conventional view of the substrate–cyclodextrin interaction was formed that has persisted in spite of numerous contradicting observations. Here the shortcomings of the phase-solubility method are elucidated. The limited permeability of drug/cyclodextrin complexes through semi-permeable membrane, as well as osmometric data and images from transition electronic microscopy (TEM) are used as convincing evidences of aggregation of cyclodextrins and their complexes. The necessity of updating the existing notions of cyclodextrin complexation is discussed.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, 107, Reykjavik, Iceland

    Sergey V. Kurkov, Elena V. Ukhatskaya & Thorsteinn Loftsson

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  1. Sergey V. Kurkov
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  2. Elena V. Ukhatskaya
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  3. Thorsteinn Loftsson
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Correspondence to Thorsteinn Loftsson.

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Kurkov, S.V., Ukhatskaya, E.V. & Loftsson, T. Drug/cyclodextrin: beyond inclusion complexation. J Incl Phenom Macrocycl Chem 69, 297–301 (2011). https://doi.org/10.1007/s10847-010-9756-x

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  • DOI: https://doi.org/10.1007/s10847-010-9756-x

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