Novel chemo-enzymatic access to amphiphilic cyclodextrins

  • Audrey Favrelle
  • Véronique Bonnet
  • Catherine Sarazin
  • Florence Djedaïni-Pilard
Original Article


A new class of mono-substituted amphiphilic cyclodextrins was synthesized in a one-step lipase catalysed amidification. Microbial and animal lipases were able to catalyse this reaction. Depending on the acyl donors, various hydrophobic moieties have been grafted on methylated β-cyclodextrin. Azoninyl-methylated-β-cyclodextrin derivatives were also obtained by reaction of acetaldehyde and modified cyclodextrins in presence of dedicated lipase.


Amidification Amphiphilic Cyclodextrin Fatty acids Lipase Solvent free medium Vinyl esters 


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Copyright information

© Springer Science+Business Media, Inc. 2007

Authors and Affiliations

  • Audrey Favrelle
    • 1
    • 2
  • Véronique Bonnet
    • 1
  • Catherine Sarazin
    • 2
  • Florence Djedaïni-Pilard
    • 1
  1. 1.Laboratoire de GlucidesUMR 6219, Université de Picardie Jules VerneAmiens CedexFrance
  2. 2.Génie Enzymatique et Cellulaire, UMR 6022Université de Picardie Jules VerneAmiensFrance

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