Catheter ablation for monomorphic ventricular tachycardia in Brugada syndrome patients: detailed characteristics and long-term follow-up

  • Sayuri TokiokaEmail author
  • Seiji Fukamizu
  • Takeshi Kitamura
  • Satoshi Miyazawa
  • Iwanari Kawamura
  • Rintaro Hojo
  • Harumizu Sakurada
  • Masayasu Hiraoka



Brugada syndrome (BrS) is a risk of sudden cardiac death due to polymorphic ventricular tachycardia and ventricular fibrillation with unusual monomorphic ventricular tachycardia (MVT). Detailed characteristics of MVT and long-term outcome of catheter ablation are still unknown. This study is aimed to identify the detailed characteristics and long-term follow-up of catheter ablation in BrS patients.


We evaluated 188 patients who were diagnosed with BrS from March 1999 to March 2018. Of those, patients who developed MVT and underwent catheter ablation were included. We identified eight MVTs in seven BrS patients.


Three of them already had implantable cardioverter-defibrillator, and MVTs were terminated by cardioversion or anti-tachycardia pacing. Four patients presented with MVT originating from the right ventricular outflow tract, one patient had MVT arising from the LV septum, one patient had MVT arising from the tricuspid annulus, and one patient had bundle branch reentry ventricular tachycardia. All MVTs were successfully treated by catheter ablation in the acute phase, and seven of eight (87.5%) were free from ventricular tachyarrhythmia during the long-term follow-up (median, 7.2 years).


All MVT cases were successfully treated by catheter ablation. We observed high ventricular arrhythmia free rate following catheter ablation during the long-term follow-up period. BrS patients who developed MVT should consider catheter ablation.


Anti-tachycardia pacing Brugada syndrome Catheter ablation Implantable cardioverter-defibrillator Monomorphic ventricular tachycardia 


Compliance with ethical standards

This retrospective observational study was approved by the Institutional Review Board of Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of CardiologyTokyo Metropolitan Hiroo HospitalTokyoJapan
  2. 2.Department of CardiologyTokyo Metropolitan Health and Hospitals Corporation Ohkubo HospitalTokyoJapan
  3. 3.Department of CardiologyTokyo Medical Dental UniversityTokyoJapan

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