The natural history of atrial fibrillation in patients with permanent pacemakers: is atrial fibrillation a progressive disease?
- 349 Downloads
Atrial fibrillation (AF) is thought to be a progressive arrhythmia, starting with short paroxysmal episodes, until eventually, it becomes permanent. Evidence for this is limited to studies with short follow-up or with minimal cardiac rhythm monitoring. We utilised the continuous rhythm monitoring capabilities of implanted pacemakers to define better the natural history of AF.
The study included 356 patients with pacemaker devices capable of continuous atrial rhythm monitoring (186 male, mean age (±SD) 79.5 ± 8.9 years). All clinical records, including history/physical examination reports, laboratory results, ECGs and Holter monitoring data were reviewed. Patients were included if AF episodes >30 s were documented. Permanent pacemaker diagnostic data were reviewed at least every 12 months. ACC/AHA/ESC guidelines were used to define AF episodes as paroxysmal, persistent or long-standing persistent/permanent.
Study follow-up period (±SD) was 7.2 ± 3.1 years. Over the study period, 179 of 356 patients (50.3 %) had at least one episode of persistent AF. Of the 356 patients, 314 (88.2 %) had paroxysmal AF and 42 (11.8 %) had persistent AF at the time of diagnosis. The predominant AF subtype, at latest follow-up, was paroxysmal for 192 patients (53.9 %), persistent for 77 (21.6 %) and long-standing persistent/permanent for 87 (24.4 %). Univariable predictors of progression to persistent AF were (1) male gender, (2) increasing left atrial diameter (LAD), (3) reduced atrial pacing (AP) and (4) increasing ventricular pacing.
Although many patients with AF will have persistent episodes, long-term continuous pacemaker follow-up demonstrates that the majority will have a paroxysmal, as opposed to persistent, form of the arrhythmia.
KeywordsAtrial fibrillation Natural history Pacemakers
RA Veasey did the conception and design, analysis and interpretation of data and drafted of the manuscript. C Sugihara revised the manuscript critically for important intellectual content. K Sandhu revised the manuscript critically for important intellectual content. G Dhillon revised the manuscript critically for important intellectual content. N Freemantle did the analysis and interpretation of data and revised the manuscript critically for important intellectual content. SS Furniss revised the manuscript critically for important intellectual content. N Sulke revised the manuscript critically for important intellectual content and final approval of the manuscript submitted.
The authors declare that they have no competing interests.
Conflict of interest
The authors state no interests which might be perceived as posing a conflict or bias.
- 2.Camm, A. J., Kirchhof, P., Lip, G. Y., et al. (2010). Guidelines for the management of atrial fibrillation: the task force for the management of atrial fibrillation of the European Society of Cardiology (ESC). European Heart Journal, 29.Google Scholar
- 7.Carlioz, O., Perrier, E., Thomas, O., et al. (2000). Accuracy of atrial tachyarrhythmia monitoring in a Selection device: correlation with an external Holter recording. Europace, 1(Suppl D), 9–10.Google Scholar
- 9.Jarwe, M., Klug, D., Marquie, C., et al. (2001). Description of an atrial tachyarrhythmia patient population with a dual chamber pacemaker. Europace, 2(Abstract Suppl), A20.Google Scholar
- 13.Fuster, V., Ryden, L. E., Cannom, D. S., et al. (2006). ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: full text: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 guidelines for the management of patients with atrial fibrillation) developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society. Europace, 8(9), 651–745.CrossRefPubMedGoogle Scholar
- 20.Nagarakanti, R., Saksena, S., Hettrick, D., et al. (2011). Progression of new onset to established persistent atrial fibrillation: an implantable device-based analysis with implications for clinical classification of persistent atrial fibrillation. Journal of Interventional Cardiac Electrophysiology, 32(1), 7–15.CrossRefPubMedGoogle Scholar