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The comparison of epicardial focused ultrasound circumferential pulmonary vein ablation and BOX ablation—results from experimental acute atrial fibrillation

  • Shaojie Chen
  • Zhiyu Ling
  • Yuehui YinEmail author
  • Chengzhi Li
  • Bo Zhang
  • Bernhard Zrenner
  • Mitchell W. Krucoff
Article
  • 124 Downloads

Abstract

Purpose

The purpose of this study was to compare the efficacy of focused ultrasound circumferential pulmonary vein ablation (CPVa) and BOX ablation (BOXa) in an acute atrial fibrillation (AF) model.

Methods

Twenty mongrel dogs were divided into either CPVa or BOXa groups. CPV or BOX focused ultrasonic ablation was conducted in each group after successful establishment of the AF model. Before-and-after ablation left atrial effective refractory period (LAERP), AF inducibility, and induced AF lasting time were measured in both groups.

Results

The LAERP after AF model establishment was significantly shorter than that before establishment (102 ± 10 vs. 140 ± 10 ms, p < 0.01, in the CPVa group; 105 ± 8 vs. 139 ± 11 ms, p < 0.01, in the BOXa group). The AF inducibility after ablation was significantly lower than that before ablation in the two groups (98% vs. 28%, p < 0.01, in the CPVa group; 97% vs.14%, p < 0.01, in the BOXa group), and the induced AF lasting time after ablation was significantly shorter than that before ablation in both groups (233 ± 40 vs. 70 ± 29 s, p < 0.01, in the CPVa group; 240 ± 41 vs. 34 ± 22 s, p < 0.01, in the BOXa group). On intergroup comparison, AF inducibility and induced AF lasting time after ablation were significantly lower/shorter in the BOXa group than those in the CPVa group (14% vs. 28%, p = 0.021; 34 ± 22 vs. 70 ± 29 s, p = 0.048, respectively).

Conclusions

In the experimental AF model, the epicardial focused ultrasound BOX ablation may be more effective to prevent the recurrence of AF compared with the CPV approach.

Keywords

Atrial fibrillation Focused ultrasound ablation BOX ablation Circumferential pulmonary vein ablation 

Abbreviations

AF

Atrial fibrillation

BOXa

Box ablation

CPVa

Circumferential pulmonary vein ablation

LAERP

Left atrial effective refractory period

IALT

Induced AF lasting time

LA (A)

Left atria (appendage)

RA (A)

Right atria (appendage)

L (R) PV

Left (right) pulmonary vein

Notes

Acknowledgments

This study was supported by the Health Bureau, Science Committee, ChongQing and Natural Science Foundation, China.

Conflicts of interest

None.

References

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Shaojie Chen
    • 1
  • Zhiyu Ling
    • 1
  • Yuehui Yin
    • 1
    Email author
  • Chengzhi Li
    • 2
  • Bo Zhang
    • 1
  • Bernhard Zrenner
    • 3
  • Mitchell W. Krucoff
    • 4
  1. 1.The Department of CardiologyThe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina
  2. 2.Biomedical Engineering CollegeChongqing Medical UniversityChongqingChina
  3. 3.Medizinische KlinikKrankenhaus Landshut/AchdorfLandshutGermany
  4. 4.Duke University Medical CenterDurhamUSA

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