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A detailed anatomical and mathematical model of the hippocampal formation for the generation of sharp-wave ripples and theta-nested gamma oscillations

  • Amélie Aussel
  • Laure Buhry
  • Louise Tyvaert
  • Radu Ranta
Article
  • 101 Downloads

Abstract

The mechanisms underlying the broad variety of oscillatory rhythms measured in the hippocampus during the sleep-wake cycle are not yet fully understood. In this article, we propose a computational model of the hippocampal formation based on a realistic topology and synaptic connectivity, and we analyze the effect of different changes on the network, namely the variation of synaptic conductances, the variations of the CAN channel conductance and the variation of inputs. By using a detailed simulation of intracerebral recordings, we show that this is able to reproduce both the theta-nested gamma oscillations that are seen in awake brains and the sharp-wave ripple complexes measured during slow-wave sleep. The results of our simulations support the idea that the functional connectivity of the hippocampus, modulated by the sleep-wake variations in Acetylcholine concentration, is a key factor in controlling its rhythms.

Keywords

Hippocampal oscillations Conductance-based neurons Sleep-wake cycle Sharp-wave ripples Theta-nested gamma oscillations Acetylcholine 

Notes

Compliance with Ethical Standards

Conflict of interests

The authors declare that they have no conflict of interest.

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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Laboratoire Lorrain de Recherche en Informatique et ses applicationsLORIA UMR 7503, University of Lorraine-INRIA-CNRS, F-54506Vandoeuvre les NancyFrance
  2. 2.Centre de Recherche en Automatique de NancyCRAN-CNRS UMR 7039 University of LorraineVandoeuvre les NancyFrance
  3. 3.Department of NeurologyCHU de NancyNancyFrance

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