Journal of Computational Neuroscience

, Volume 42, Issue 2, pp 177–185

Propagation and synchronization of reverberatory bursts in developing cultured networks

  • Chih-Hsu Huang
  • Yu-Ting Huang
  • Chun-Chung Chen
  • C. K. Chan
Article

DOI: 10.1007/s10827-016-0634-4

Cite this article as:
Huang, CH., Huang, YT., Chen, CC. et al. J Comput Neurosci (2017) 42: 177. doi:10.1007/s10827-016-0634-4
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Abstract

Developing networks of neural systems can exhibit spontaneous, synchronous activities called neural bursts, which can be important in the organization of functional neural circuits. Before the network matures, the activity level of a burst can reverberate in repeated rise-and-falls in periods of hundreds of milliseconds following an initial wave-like propagation of spiking activity, while the burst itself lasts for seconds. To investigate the spatiotemporal structure of the reverberatory bursts, we culture dissociated, rat cortical neurons on a high-density multi-electrode array to record the dynamics of neural activity over the growth and maturation of the network. We find the synchrony of the spiking significantly reduced following the initial wave and the activities become broadly distributed spatially. The synchrony recovers as the system reverberates until the end of the burst. Using a propagation model we infer the spreading speed of the spiking activity, which increases as the culture ages. We perform computer simulations of the system using a physiological model of spiking networks in two spatial dimensions and find the parameters that reproduce the observed resynchronization of spiking in the bursts. An analysis of the simulated dynamics suggests that the depletion of synaptic resources causes the resynchronization. The spatial propagation dynamics of the simulations match well with observations over the course of a burst and point to an interplay of the synaptic efficacy and the noisy neural self-activation in producing the morphology of the bursts.

Keywords

Bursting Reverberation Synchronization Cultured network Simulation 

Supplementary material

10827_2016_634_MOESM1_ESM.zip (6.6 mb)
(ZIP 6.56 MB)

Funding information

Funder NameGrant NumberFunding Note
Ministry of Science and Technology, Taiwan
  • 102-2112-M-001 -009 -MY3
Physics Division, National Center for Theoretical Sciences (TW)

    Copyright information

    © Springer Science+Business Media New York 2016

    Authors and Affiliations

    1. 1.Institute of PhysicsAcademia SinicaTaipeiRepublic of China
    2. 2.Department of Physics and Center for Complex SystemsNational Central UniversityChungliRepublic of China

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