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Journal of Computational Neuroscience

, Volume 39, Issue 2, pp 197–216 | Cite as

Generalized seizures in a neural field model with bursting dynamics

  • X. ZhaoEmail author
  • P. A. Robinson
Article
First Online:

Abstract

The mechanisms underlying generalized seizures are explored with neural field theory. A corticothalamic neural field model that has accounted for multiple brain activity phenomena and states is used to explore changes leading to pathological seizure states. It is found that absence seizures arise from instabilities in the system and replicate experimental studies in numerous animal models and clinical studies.

Keywords

Neural-field theory Corticothalamic Generalized seizures 
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Notes

Acknowledgments

This work was supported by the Australian Research Council Center of Excellence for Integrative Brain Function (ARC Grant CE140100007) and by ARC Grant FL1401000225.

Conflict of Interest

The authors declare that they have no conflict of interest.

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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.School of PhysicsThe University of SydneySydneyAustralia
  2. 2.Center for Integrative Brain FunctionUniversity of SydneyNSWAustralia
  3. 3.NeurosleepGlebeAustralia
  4. 4.Cooperative Research Center for Alertness, Safety, and ProductivityUniversity of SydneyNSWAustralia

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