Journal of Computational Neuroscience

, Volume 28, Issue 1, pp 137–154 | Cite as

Models of cortical networks with long-range patchy projections

  • Nicole Voges
  • Christian Guijarro
  • Ad Aertsen
  • Stefan Rotter
Article

Abstract

The cortex exhibits an intricate vertical and horizontal architecture, the latter often featuring spatially clustered projection patterns, so-called patches. Many network studies of cortical dynamics ignore such spatial structures and assume purely random wiring. Here, we focus on non-random network structures provided by long-range horizontal (patchy) connections that remain inside the gray matter. We investigate how the spatial arrangement of patchy projections influences global network topology and predict its impact on the activity dynamics of the network. Since neuroanatomical data on horizontal projections is rather sparse, we suggest and compare four candidate scenarios of how patchy connections may be established. To identify a set of characteristic network properties that enables us to pin down the differences between the resulting network models, we employ the framework of stochastic graph theory. We find that patchy projections provide an exceptionally efficient way of wiring, as the resulting networks tend to exhibit small-world properties with significantly reduced wiring costs. Furthermore, the eigenvalue spectra, as well as the structure of common in- and output of the networks suggest that different spatial connectivity patterns support distinct types of activity propagation.

Keywords

Cortical network model Horizontal synaptic connectivity Wiring optimization Stochastic graph theory 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Nicole Voges
    • 1
    • 2
    • 4
  • Christian Guijarro
    • 2
  • Ad Aertsen
    • 1
    • 2
  • Stefan Rotter
    • 1
    • 3
  1. 1.Bernstein Center for Computational Neuroscience FreiburgAlbert-Ludwig UniversityFreiburgGermany
  2. 2.Neurobiology & Biophysics, Faculty of BiologyAlbert-Ludwig UniversityFreiburgGermany
  3. 3.Computational Neuroscience, Faculty of BiologyAlbert-Ludwig UniversityFreiburgGermany
  4. 4.INSERMUMR 751 Universite Aix-MarseilleMarseille Cedex 05France

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