Journal of Computational Neuroscience

, Volume 23, Issue 2, pp 143–168

Somato-dendritic mechanisms underlying the electrophysiological properties of hypothalamic magnocellular neuroendocrine cells: A multicompartmental model study

  • Alexander O. Komendantov
  • Natalia A. Trayanova
  • Jeffrey G. Tasker
Article

DOI: 10.1007/s10827-007-0024-z

Cite this article as:
Komendantov, A.O., Trayanova, N.A. & Tasker, J.G. J Comput Neurosci (2007) 23: 143. doi:10.1007/s10827-007-0024-z

Abstract

Magnocellular neuroendocrine cells (MNCs) of the hypothalamus synthesize the neurohormones vasopressin and oxytocin, which are released into the blood and exert a wide spectrum of actions, including the regulation of cardiovascular and reproductive functions. Vasopressin- and oxytocin-secreting neurons have similar morphological structure and electrophysiological characteristics. A realistic multicompartmental model of a MNC with a bipolar branching structure was developed and calibrated based on morphological and in vitro electrophysiological data in order to explore the roles of ion currents and intracellular calcium dynamics in the intrinsic electrical MNC properties. The model was used to determine the likely distributions of ion conductances in morphologically distinct parts of the MNCs: soma, primary dendrites and secondary dendrites. While reproducing the general electrophysiological features of MNCs, the model demonstrates that the differential spatial distributions of ion channels influence the functional expression of MNC properties, and reveals the potential importance of dendritic conductances in these properties.

Keywords

Hypothalamic neuron Oxytocin Vasopressin Dendritic conductance Multicompartmental model 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Alexander O. Komendantov
    • 1
    • 5
  • Natalia A. Trayanova
    • 1
    • 2
  • Jeffrey G. Tasker
    • 1
    • 3
    • 4
  1. 1.Center for Computational ScienceTulane UniversityNew OrleansUSA
  2. 2.Department of Biomedical EngineeringJohns Hopkins UniversityBaltimoreUSA
  3. 3.Division of Neurobiology, Department of Cell and Molecular BiologyTulane UniversityNew OrleansUSA
  4. 4.Neuroscience ProgramTulane UniversityNew OrleansUSA
  5. 5.Department of Neurobiology and AnatomyDrexel University College of MedicinePhiladelphiaUSA

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