Journal of Computational Neuroscience

, Volume 22, Issue 1, pp 63–80 | Cite as

Mechanisms of seizure propagation in a cortical model

  • Mark A. Kramer
  • Andrew J. Szeri
  • James W. Sleigh
  • Heidi E. Kirsch


We consider a mathematical model of mesoscopic human cortical ictal electrical activity. We compare the model results with ictal electrocortical data recorded from three human subjects and show how the two agree. We determine that, in the model system, seizures result from increased connectivity between excitatory and inhibitory cell populations, or from decreased connectivity within either excitatory or inhibitory cell populations. We compare the model results with the disinhibition and 4-AP models of epilepsy and suggest how the model may guide the development of new anticonvulsant therapies.


Epilepsy Seizure Electrocortiogram Human Mesoscopic cortical dynamics 


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Copyright information

© Springer Science + Business Media, LLC 2006

Authors and Affiliations

  • Mark A. Kramer
    • 1
    • 2
  • Andrew J. Szeri
    • 3
    • 1
  • James W. Sleigh
    • 4
  • Heidi E. Kirsch
    • 5
  1. 1.Applied Science and Technology Graduate GroupUniversity of CaliforniaBerkeleyUSA
  2. 2.Center for BioDynamicsBoston UniversityBostonUSA
  3. 3.Department of Mechanical EngineeringUniversity of CaliforniaBerkeleyUSA
  4. 4.Waikato Clinical SchoolWaikato HospitalHamiltonNew Zealand
  5. 5.Department of NeurologyUniversity of CaliforniaSan FranciscoUSA

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