Two Cortical Circuits Control Propagating Waves in Visual Cortex
- 122 Downloads
Visual stimuli produce waves of activity that propagate across the visual cortex of fresh water turtles. This study used a large-scale model of the cortex to examine the roles of specific types of cortical neurons in controlling the formation, speed and duration of these waves. The waves were divided into three components: initial depolarizations, primary propagating waves and secondary waves. The maximal conductances of each receptor type postsynaptic to each population of neurons in the model was systematically varied and the speed of primary waves, durations of primary waves and total wave durations were measured. The analyses indicate that wave formation and speed are controlled principally by feedforward excitation and inhibition, while wave duration is controlled principally by recurrent excitation and feedback inhibition.
Keywordsinhibitory interneurons recurrent excitation feedback inhibition
Unable to display preview. Download preview PDF.
- Bower JM, Beeman D (1998) The Book of Genesis, 2nd ed. TELOS, New York.Google Scholar
- Chervin RD, Pierce PA, Connors BW (1988) Periodicity and directionality in the propagation of epileptiform dischargers across neocortex. J. Neurophysiol. 61: 747–758.Google Scholar
- Colombe JB, Ulinski PS (1999) Temporal dispersion windows in cortical neurons. J. Comput. Neurosci. 17: 3894–3906.Google Scholar
- Du X, Ghosh BK, Ulinski PS (2005) Encoding and decoding target locations with waves in the turtle visual cortex. IEEE Trans. Biomed. Eng. 52: 566–577.Google Scholar
- Ghanzafar AA, Nicoleilis MAL (1999) Spatiotemporal properties of layer V neurons of the rat primary somatosensory cortex. Cerebral Cortex 9: 348–361.Google Scholar
- Seidemann E, Arieli A, Grinvald A, Slovin H (2002) Dynamics of depolarization and hyperpolarization in the frontal cortex and saccade goal. Science 305: 862–865.Google Scholar
- Traub RD, Jefferys JGR, Miles R, Michelson H (1993) Analysis of the propagation of disinhibition-induced afer-discharges along the guine-pig hippocampual slice in vitro. J. Physiol. (Lond.) 472: 267–287.Google Scholar
- Ulinski PS (1999) Neural mechanisms underlying the analysis of moving visual stimuli. In: Ulinski PS, Jones EG, Peters A, eds. Cerebral Cortex. Vol. 13. Models of Cortical Circuitry. Plenum Press, New York, pp. 283–399.Google Scholar
- Wang W (2006) Dynamics of the turtle visual cortex and design of sensor networks. D.Sc. thesis. Washington University, Saint Louis, MO.Google Scholar