Journal of Computer-Aided Molecular Design

, Volume 25, Issue 2, pp 103–106 | Cite as

Guiding effective decisions: an interview with Matthew Segall, CEO of Optibrium

  • Wendy A. WarrEmail author
Warr’s Piece

Open image in new window Matt Segall has an M. Sc. in computation from the University of Oxford and a Ph.D. in theoretical physics from the University of Cambridge. As Associate Director at Camitro (UK), ArQule Inc. and then Inpharmatica, he led a team developing predictive ADME models and state-of-the-art, intuitive, decision-support and visualization tools for drug discovery. In January 2006, he became responsible for management of Inpharmatica’s ADME business, including experimental ADME services and the StarDrop [1] software platform. Following acquisition of Inpharmatica, Matt became Senior Director responsible for BioFocus’s ADMET division and in 2009 led a management buyout of the StarDrop business to found Optibrium.



Optibrium has been here at this very attractive science park (IQ Cambridge) for about 18 months now. Whats the history?


Ed Champness (our CSO) and I founded Optibrium in 2009 as a spin-out of BioFocus. We had been responsible for the development...


Physical Chemistry Theoretical Physic Drug Discovery Activity Relationship Structure Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    StarDrop. Optibrium Ltd., 7226 IQ Cambridge, Beach Drive, Cambridge, CB25 9TL, UK. Accessed Dec 2010
  2. 2.
    Warr WA (2009) ChEMBL. An interview with John Overington, team leader, chemogenomics at the European Bioinformatics Institute Outstation of the European Molecular Biology Laboratory (EMBL-EBI). J Comput Aided Mol Des 23(4):195–198CrossRefGoogle Scholar
  3. 3.
    CACTVS. Xemistry GmbH, Hainholzweg 11, D-61462 Königstein, Germany. Accessed Dec 2010
  4. 4.
    Molecular Networks. Molecular Networks GmbH - Computerchemie, Henkestrasse 91, 91052 Erlangen, Germany. Accessed Dec 2010
  5. 5.
    Pipeline Pilot. Accelrys, Inc., 10188 Telesis Court, Suite 100, San Diego, CA 92121, USA. Accessed Dec 2010
  6. 6.
    Stewart KD, Shiroda M, James CA (2006) Drug Guru: a computer software program for drug design using medicinal chemistry rules. Bioorg Med Chem 14(20):7011–7022CrossRefGoogle Scholar
  7. 7.
    QikProp. 120 West 45th Street, 17th Floor, Tower 45, New York, NY 10036-4041, USA. Accessed Dec 2010
  8. 8.
    ADMET Predictor. Simulations Plus, 42505 10th Street West, Lancaster, CA 93534-7059, USA. Accessed Dec 2010
  9. 9.
    ACD/ADME Suite. Advanced Chemistry Development, Inc., 110 Yonge Street, 14th floor, Toronto, Ontario, Canada M5C 1T4. Accessed Dec 2010
  10. 10.
    MetaSite. Molecular Discovery, Via Stoppani, 38, 06135 Ponte San Giovanni, Perugia, Italy. Accessed Dec 2010
  11. 11.
    SARchitect. Strand Life Sciences, 5th Floor, Kirloskar Business Park, Bellary Road, Hebbal, Bangalore, 560024, India. Accessed Dec 2010
  12. 12.
    MOE. Chemical Computing Group, 1010 Sherbrooke St. W, Suite 910, Montreal, Quebec, Canada H3A 2R7. Accessed Dec 2010
  13. 13.
    SYBYL-X. Tripos Inc., Tripos, 1699 South Hanley Road, St. Louis, MO 63144-2319, USA.,SimplePage,,,&page=comp_informatics&s=0. Accessed Dec 2010
  14. 14.
    Discovery Studio. Accelrys, Inc., 10188 Telesis Court, Suite 100, San Diego, CA 92121, USA. Accessed Dec 2010
  15. 15.
    Obrezanova O, Gola JMR, Champness E, Segall MD (2008) Automatic QSAR modeling of ADME properties: blood-brain barrier penetration and aqueous solubility. J Comput Aided Mol Des 22(6–7):431–440CrossRefGoogle Scholar
  16. 16.
    The Optibrium community. Accessed Dec 2010
  17. 17.
    TIBCO Spotfire. Tibco Software, Inc., 212 Elm Street, Somerville, MA 02144, USA. Accessed Dec 2010
  18. 18.
    Vortex. Dotmatics Ltd.,The Old Monastery, Windhill, Bishops Stortford, Herts CM23 2ND, UK. Accessed Dec 2010
  19. 19.
    SEURAT. Synaptic Science LLC, 155 Gibbs St, Suite 430, Rockville, MD 20850-0353, USA. Accessed Dec 2010
  20. 20.
    Chadwick A, Segall M (2010) Overcoming psychological barriers to good discovery decisions. Drug Discov Today 15(13/14):561–569CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Wendy Warr & AssociatesCheshireUK

Personalised recommendations