Journal of Computer-Aided Molecular Design

, Volume 21, Issue 9, pp 523–525 | Cite as

IA, database of known ligands of aminoacyl-tRNA synthetases

  • Mieczyslaw Torchala
  • Marcin Hoffmann


The IA database contains 240 structures of known inhibitors of aminoacyl-tRNA synthetases. Structures can be downloaded in different file formats (mol, sdf, smile, png). The search engine offers possibility of searching for the ligands with a given functional group. Additionally, one can search for ligands that act on selected synthetases and from particular references. The data include information which synthetase a given ligand inhibits together with the inhibition constant (IC50) if known. Database is freely available at


Aminoacyl-tRNA synthetases Aminoacyl-tRNA synthetases inhibitors Molecular docking Virtual high throughput screening 



Financial support by European Commission and Polish Ministry for Education and Science is acknowledged (BioSapiens project grant number LSHG-CT-2003-503265, and grant number PBZ-MNiI-2/1/2005). MH thanks the Foundation for Polish Science for support via FOCUS program. The authors thank the anonymous referee for the suggestions on improving the IA database.


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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  1. 1.BioInfoBank InstitutePoznanPoland
  2. 2.Faculty of PhysicsAdam Mickiewicz UniversityPoznanPoland
  3. 3.Faculty of ChemistryAdam Mickiewicz UniversityPoznanPoland

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