Women’s morbid conditions are associated with decreased odds of live birth in the first IVF/ICSI treatment: a retrospective single-center study

  • Juan J. TarínEmail author
  • Eva Pascual
  • Miguel-Ángel García-Pérez
  • Raúl Gómez
  • Antonio Cano
Assisted Reproduction Technologies



The present study aims to ascertain whether there is a causal relationship between women’s disease conditions present at the starting time of the first intended oocyte retrieval cycle and IVF/ICSI outcomes, primarily odds of live birth in the first IVF/ICSI treatment.


This is a retrospective study of infertile healthy and diseased women that had a live birth and/or exhibited a complete first oocyte retrieval cycle. Generalized Estimating Equations (GEE) models were applied to adjust standard errors for the potential correlation among women exhibiting the same infertility etiology. Confounders to be controlled for in these GEE models were previously selected following a strict stepwise methodology.


Compared to healthy women, diseased women exhibited lower odds of live birth (OR (95% CI) 0.704 (0.576–0.860)). Further screening analyses indicated that subclinical iodine-deficiency hypothyroidism together with autoimmune thyroiditis contributed significantly to decrease odds of live birth (OR (95% CI) 0.720 (0.608–0.853)). Another important contribution arose from practically all the remaining morbid conditions analyzed. These diseases were individually associated with lower odds of live birth, although differences were non-significant. Notwithstanding, differences became significant after merging these diseases in a single group (OR (95% CI) 0.605 (0.394–0.930)).


There is a significant causal association between most diseases present at the starting time of the first intended oocyte retrieval cycle and lower odds of live birth in the first IVF/ICSI treatment.


Disease conditions Infertility etiology In vitro fertilization Cumulative live birth Morbid conditions 


Compliance with ethical standards

This study was approved by the Ethical Committee of Clinical Investigation, Valencia University Clinical Hospital on November 30th 2017 (2017/316).


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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Cellular Biology, Functional Biology and Physical Anthropology, Faculty of Biological SciencesUniversity of ValenciaBurjassotSpain
  2. 2.Institute of Health Research INCLIVAValenciaSpain
  3. 3.Department of Genetics, Faculty of Biological SciencesUniversity of ValenciaBurjassotSpain
  4. 4.Department of Pediatrics, Obstetrics and Gynecology, Faculty of MedicineUniversity of ValenciaValenciaSpain
  5. 5.Service of Obstetrics and GynecologyUniversity Clinic HospitalValenciaSpain

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