Journal of Assisted Reproduction and Genetics

, Volume 36, Issue 1, pp 173–174 | Cite as

Is it realistic to consider vitamin D as a follicular and serum marker of human oocyte quality?

  • Mauro CozzolinoEmail author
Letter to the Editor

Over the past decade, vitamin D has been spotlighted in many research fields. Nevertheless, numerous publications suggest that its influence on reproductive health is still ambiguous. One of the hypothesis on the importance of vitamin D on the outcomes of Assisted Reproductive Technologies arises from their possible effects on endometrial receptivity and immune-modulating effects.

In Ciepiela et al.’s study, the authors demonstrated that patients with vitamin D < 20 ng/ml in follicular fluid had greater probability of having positive hCG; suggesting that vitamin D in follicular fluid could play a role in oocyte development and embryo quality [1]. Having found no significant differences of serum levels between patients with vitamin D < 20 ng/ml or > 20 ng/ml in terms of age, the number of retrieved oocytes, the number of mature MII oocytes, the number of cycles with no available embryo for embryo transfer, and percentage of top quality embryos, Ciepiela et al.’s results are very...



I would like to warmly thank Mr. Herman David Lòpez Jìmenez (Translinguo Global) for reviewing the use of the English language of the manuscript and for valuable linguistic advice that greatly improved the paper.

Compliance with ethical standards

Conflict of interest

The author declares that he has no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Instituto Valenciano de InfertilidadIVI-RMA MadridMadridSpain

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