Journal of Assisted Reproduction and Genetics

, Volume 36, Issue 2, pp 335–340 | Cite as

Deliveries following fertility preservation by ovarian tissue cryopreservation without autotransplantation—what should be expected?

  • Daniel LantsbergEmail author
  • Adel Farhi
  • Inna Zaslavsky-Paltiel
  • Barbara G. Silverman
  • Liat Lerner-Geva
  • Raoul Orvieto
Fertility Preservation



To evaluate the delivery rate and to characterize patients following ovarian tissue cryopreservation (OTCP) who did not undergo auto-transplantation.

Methods and Materials

All consecutive cancer patients admitted to our IVF unit, from January 2004 to December 2015, who underwent OTCP for the purpose of fertility preservation without autotransplantation were analyzed. The cohort included 338 patients and was linked to the National Live Birth registry of the Israel Ministry of Health in order to determine whether the women delivered following the cancer diagnosis.

Main outcome measures

Delivery rate following OTCP without autotransplantation.


During 6.4 years of follow-up, 30% of the patients delivered, with no differences in gravity, age at first diagnosis of cancer, type of malignancy, or the prevalence of relapse of malignancy between those who delivered and those who did not. Moreover, in multivariate analysis, those undergoing OTCP before the age of 30 and those suffering from breast cancer had significantly higher odds to conceive and deliver following cancer treatment without the need of autotransplantation.


Further studies are required to elucidate the appropriate subgroup of patients with breast cancer under the age of 30 years, who will need OTCP. This information might aid both fertility specialists’ counseling and their oncological patients in pursuing the appropriate fertility preservation strategy.


Fertility preservation Ovarian tissue cryopreservation Pregnancy after chemotherapy Gonadotoxic treatment 


Compliance with ethical standards

This study was approved by the Institutional Review board (No. 2951-16-SMC).

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Daniel Lantsberg
    • 1
    • 2
    • 3
    Email author
  • Adel Farhi
    • 4
  • Inna Zaslavsky-Paltiel
    • 4
  • Barbara G. Silverman
    • 3
    • 5
  • Liat Lerner-Geva
    • 3
    • 4
  • Raoul Orvieto
    • 1
    • 3
    • 6
  1. 1.IVF Unit, Obstetric and Gynecology DepartmentSheba Medical CenterTel HashomerIsrael
  2. 2.Lis Maternity and Women’s Hospital, Tel-Aviv Sourasky Medical CenterTel-AvivIsrael
  3. 3.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  4. 4.Women and Children’s Health Research UnitGertner Institute for Epidemiology & Health Policy Research LtdTel HashomerIsrael
  5. 5.Israel National Cancer RegistryIsrael Ministry of HealthTel AvivIsrael
  6. 6.The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Sackler Faculty of MedicineTel-Aviv UniversityTel AvivIsrael

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