Journal of Assisted Reproduction and Genetics

, Volume 36, Issue 2, pp 179–187 | Cite as

The role of microRNAs in human embryo implantation: a review

  • Anthea B. M. Paul
  • Seifeldin T. Sadek
  • Arnold M. MahesanEmail author


MicroRNAs (miRNAs) are emerging as important in human embryo implantation, and we present here a review of the literature from a clinical perspective. Implantation involves complex interactions between the blastocyst and endometrium. miRNAs have been shown to be differentially expressed in implanted compared with non-implanted blastocysts and euploid compared with aneuploid blastocysts. Further, miRNAs are differentially expressed in proliferative compared with decidualized endometrium, and in receptive compared with pre-receptive endometrium. miRNAs are also differentially expressed in endometrium of women who failed implantation, and in endometrium of women with recurrent implantation failure. Due to the complexity of miRNA signaling, studies have suffered from inconsistency in reproducibility of results. However, miRNAs show potential as biomarkers in the pursuit of more reliable prediction of embryo implantation.


MicroRNA Human embryo Endometrium Implantation Pregnancy Recurrent implantation failure 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest

Supplementary material

10815_2018_1326_MOESM1_ESM.docx (16 kb)
Supplementary Table 1 (DOCX 15 kb)


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineUniversity of OttawaOttawaCanada
  2. 2.The Jones Institute for Reproductive MedicineEastern Virginia Medical SchoolNorfolkUSA

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