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Journal of Assisted Reproduction and Genetics

, Volume 35, Issue 8, pp 1395–1399 | Cite as

Endometriosis does not affect live birth rates of patients submitted to assisted reproduction techniques: analysis of the Latin American Network Registry database from 1995 to 2011

  • Mário Murta
  • Roberto Carlos Machado
  • Fernando Zegers-Hochschild
  • Miguel Angel Checa
  • Marcos Sampaio
  • Selmo Geber
Reproductive Physiology and Disease
  • 105 Downloads

Abstract

Purpose

The purpose of this study is to compare the results of ART treatment in patients with and without endometriosis in a large cohort of patients from different centers over an extented period of time.

Methods

This retrospective study is using data from patients undergoing 27,294 cycles of IVF/ICSI treatment between 1995 and 2011 that were registered in the database of the Latin American Registry maintained by the Latin America Network of Assisted Reproduction.

Results

The mean number of retrieved oocytes was higher in the control group, but the mean number of metaphase II oocytes was similar. Fertilization rate and transfer rate were higher in the control group. We observed higher pregnancy rates, per cycle initiated and per embryo transfer and higher live birth rate in the endometriosis group. In the group of patients with 25–35 years old, the number of oocytes, fertilization rate, and number of transferred embryos were significantly higher in the control group. However, pregnancy rate and live birth rate were higher in the endometriosis group. In the group of patients with 36–40 years old, the number of transferred embryos was higher in the control group, but the pregnancy rate and live birth rate were higher in the endometriosis group. In the group of patients with 41 to 42 years old, the number of transferred embryos and the transfer rate were higher in the control group, but the pregnancy rate was higher in the endometriosis group.

Conclusion

Our results demonstrate that endometriosis does not affect the outcome of patients subjected to IVF/ICSI and although patients with endometriosis present lower number of oocytes and higher cancelation rate, these shortcomings do not reduce pregnancy and live birth rates.

Keywords

Endometriosis Assisted reproduction Pregnancy Take home baby 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

References

  1. 1.
    Kennedy S, Bergqvist A, Chapron C, D’Hooghe T, Dunselman G, Greb R, et al. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 2005;20:2698–704.CrossRefPubMedGoogle Scholar
  2. 2.
    Johnson NP, Hummelshoj L, for The World Endometriosis Society Montpellier Consortium. Consensus on current management of endometriosis. Hum Reprod. 2013;28:1552–68.CrossRefPubMedGoogle Scholar
  3. 3.
    Adamson GD, Kennedy SH, Hummelshoj L. Creating solutions in endometriosis: global collaboration through the World Endometriosis Research Foundation. J Endometr. 2010;2:3–6.CrossRefGoogle Scholar
  4. 4.
    Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012;39:535–49.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Dmowski WP, Pry M, Ding J, Rana N. Cycle-specific and cumulative fecundity in patients with endometriosis who are undergoing controlled ovarian hyperstimulation-intrauterine insemination or in vitro fertilization-embryo transfer. Fertil Steril. 2002;78:750–6.CrossRefPubMedGoogle Scholar
  6. 6.
    Ozkan S, Arici A. Advances in treatment options of endometriosis. Gynecol Obstet Investig. 2009;67:81–91.CrossRefGoogle Scholar
  7. 7.
    Simón C, Gutiérrez A, Vidal A, de los Santos MJ, Tarín JJ, Remohí J, et al. Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation. Hum Reprod. 1994;9:725–9.CrossRefPubMedGoogle Scholar
  8. 8.
    Barnhart K, Dunsmoor-Su R, Coutifaris C. Effect of endometriosis on in vitro fertilization. Fertil Steril. 2002;77:1148–55.CrossRefPubMedGoogle Scholar
  9. 9.
    Coccia ME, Rizzello F, Mariani G, Bulletti C, Palagiano A, Scarselli G. Impact of endometriosis on in vitro fertilization and embryo transfer cycles in young women: a stage-dependent interference. Acta Obstet Gynecol Scand. 2011;90:1232–8.CrossRefPubMedGoogle Scholar
  10. 10.
    Harb HM, Gallos ID, Chu J, Harb M, Coomarasamy A. The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis. BJOG. 2013;120:1308–20.CrossRefPubMedGoogle Scholar
  11. 11.
    Rossi AC, Prefumo F. The effects of surgery for endometriosis on pregnancy outcomes following in vitro fertilization and embryo transfer: a systematic review and meta-analysis. Arch Gynecol Obstet. 2016;294:647–55.CrossRefPubMedGoogle Scholar
  12. 12.
    Bérubé S, Marcoux S, Langevin M, Maheux R. Fecundity of infertile women with minimal or mild endometriosis and women with unexplained infertility. The Canadian Collaborative Group on Endometriosis Fertil Steril 1998;69:1034–1041.Google Scholar
  13. 13.
    Geber S, Paraschos T, Atkinson G, Margara R, Winston RM. Results of IVF in patients with endometriosis: the severity of the disease does not affect outcome, or the incidence of miscarriage. Hum Reprod. 1995;10:1507–11.CrossRefPubMedGoogle Scholar
  14. 14.
    Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D. Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril. 2007;88:1568–72.CrossRefPubMedGoogle Scholar
  15. 15.
    de Ziegler D, Gayet V, Aubriot FX, Fauque P, Streuli I, Wolf JP, et al. Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes. Fertil Steril. 2010;94:2796–9.CrossRefPubMedGoogle Scholar
  16. 16.
    Opoien HK, Fedorcsak P, Omland AK, Abyholm T, Bjercke S, Ertzeid G, et al. In vitro fertilization is a successful treatment in endometriosis-associated infertility. Fertil Steril. 2012;97:912–8.CrossRefPubMedGoogle Scholar
  17. 17.
    Hamdan M, Omar SZ, Dunselman G, Cheong Y. Influence of endometriosis on assisted reproductive technology outcomes: a systematic review and meta-analysis. Obstet Gynecol. 2015;125:79–88.CrossRefPubMedGoogle Scholar
  18. 18.
    Kawwass JF, Crawford S, Session DR, Kissin DM, Jamieson DJ, National ART Surveillance System Group. Endometriosis and assisted reproductive technology: United States trends and outcomes 2000-2011. Fertil Steril. 2015;103:1537–43.CrossRefPubMedGoogle Scholar
  19. 19.
    Senapati S, Sammel MD, Morse C, Barnhart KT. Impact of endometriosis on in vitro fertilization outcomes: an evaluation of the Society for Assisted Reproductive Technologies Database. Fertil Steril. 2016;106:164–71.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Lin XN, Wei ML, Tong XM, Xu WH, Zhou F, Huang QX, et al. Outcome of in vitro fertilization in endometriosis-associated infertility: a 5-year database cohort study. Chin Med J. 2012;125:2688–93.PubMedGoogle Scholar
  21. 21.
    Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, et al. The international glossary on infertility and fertility care. Hum Reprod. 2017;32:1786–801.CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    González-Comadran M, Schwarze JE, Zegers-Hochschild F, Souza MD, Carreras R, Checa MÁ. The impact of endometriosis on the outcome of assisted reproductive technology. Reprod Biol Endocrinol. 2017;15:8–15.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Clínica NeoVitae/ORIGENGovernador ValadaresBrazil
  2. 2.Maaster Internacional Medicina ReproductivaHospital del MarBarcelonaSpain
  3. 3.The Latin American Registry of ARTMontevideoUruguay
  4. 4.Unit of Reproductive MedicineClinica las Condes, and Program of Ethics and Public Policies in Human Reproduction University Diego PortalesSantiagoChile
  5. 5.Universitat Autònoma de BarcelonaBarcelonaSpain
  6. 6.Department of Obstetrics and Gynecology, Parc de Salut MarUniversitat Autonoma de BarcelonaBarcelonaSpain
  7. 7.ORIGEN, Center for Reproductive MedicineBelo HorizonteBrazil
  8. 8.Department of Obstetrics and GynecologyUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  9. 9.Belo HorizonteBrazil

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