Impact of high magnification sperm selection on neonatal outcomes: a retrospective study

  • Olivier Gaspard
  • Pierre Vanderzwalmen
  • Barbara Wirleitner
  • Stéphanie Ravet
  • Frédéric Wenders
  • Verena Eichel
  • Alice Mocková
  • Dietmar Spitzer
  • Caroline Jouan
  • Virginie Gridelet
  • Henri Martens
  • Laurie Henry
  • Herbert Zech
  • Sophie Perrier d’Hauterive
  • Michelle Nisolle
Assisted Reproduction Technologies

Abstract

Purpose

The aim of this study was to compare the effect of the deselection of spermatozoa presenting vacuole-like structures using IMSI (intracytoplasmic morphologically selected sperm injection) with ICSI (intracytoplasmic sperm injection) by means of neonatal outcomes.

Methods

In a retrospective two-center analysis, a total of 848 successful IMSI or ICSI cycles ending with a live birth, induced abortion, or intrauterine fetal death (IUFD) were included.

Results

The IMSI and ICSI groups included 332 and 655 babies or fetuses, respectively. The parents were older in the IMSI group than in the ICSI group (mothers were 35.1 vs 32.9 years, and fathers were 39.1 vs 36.2 years). The multiple pregnancy rate was higher in the IMSI group. The mean pregnancy duration and mean birth weight were almost identical in both groups. There was no significant difference in major congenital malformations between the two groups. However, this rate was decreased in the IMSI group compared to that in the ICSI group (1.8 vs 3.2%), the difference being mainly found in singletons (1.4 vs 3.3%). Boys were more often affected than girls in both groups. The percentages of chromosomal abnormalities did not differ between the IMSI and ICSI groups (0.6 and 0.8%). The reported congenital malformations mainly affected the heart, urogenital, and musculoskeletal systems.

Conclusions

In the present study, the malformation rates observed in the IMSI and ICSI groups were not significantly different, even if slightly lower after IMSI. However, the observed difference followed the same trends observed in previous reports, indicating the possible impact of IMSI on decreasing congenital malformation occurrences. This highlights the necessity to prospectively evaluate the impact of IMSI on neonatal outcome after IVF treatment.

Keywords

Vacuole-like structures Intracytoplasmic morphologically selected sperm injection Major congenital malformations Neonatal outcomes Spermatozoa selection 

Notes

Acknowledgments

The authors thank Dr S Bulk from the Department of Genetics (Centre Hospitalier Universitaire de Liège) in Belgium for her help regarding the analysis of the babies’ neonatal data.

Compliance with ethical standards

Conflicts of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Olivier Gaspard
    • 1
  • Pierre Vanderzwalmen
    • 2
  • Barbara Wirleitner
    • 2
  • Stéphanie Ravet
    • 1
  • Frédéric Wenders
    • 1
  • Verena Eichel
    • 2
  • Alice Mocková
    • 3
  • Dietmar Spitzer
    • 4
  • Caroline Jouan
    • 1
  • Virginie Gridelet
    • 1
    • 5
  • Henri Martens
    • 5
  • Laurie Henry
    • 1
  • Herbert Zech
    • 2
    • 4
  • Sophie Perrier d’Hauterive
    • 1
  • Michelle Nisolle
    • 1
  1. 1.Centre de Procréation Médicalement Assistée – ULiègeCentre Hospitalier Universitaire de LiègeLiègeBelgium
  2. 2.IVF-Centers Prof. ZechBregenzAustria
  3. 3.Department of Neonatology, Faculty of Medicine in Pilsen and University HospitalCharles University in PraguePragueCzech Republic
  4. 4.IVF-Centers Prof. ZechSalzburgAustria
  5. 5.GIGA I3, Center of ImmunoendocrinologyUniversity of LiègeLiègeBelgium

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