Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

  • M. G. Da Broi
  • V. S. I. Giorgi
  • F. Wang
  • D. L. Keefe
  • D. Albertini
  • P. A. NavarroEmail author


An equilibrium needs to be established by the cellular and acellular components of the ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus cells (CCs) and follicular fluid (FF) are critical determinants for oocyte quality. Understanding how CCs and FF influence oocyte quality in the presence of deleterious systemic or pelvic conditions may impact clinical decisions in the course of managing infertility. Given that the functional integrities of FF and CCs are susceptible to concurrent pathological conditions, it is important to understand how pathophysiological factors influence natural fertility and the outcomes of pregnancy arising from the use of assisted reproduction technologies (ARTs). Accordingly, this review discusses the roles of CCs and FF in ensuring oocyte competence and present new insights on pathological conditions that may interfere with oocyte quality by altering the intrafollicular environment.


Oocyte Follicular fluid Cumulus cells Developmental competence 



This work was supported in part by a scholarship the Foundation for Research Support of the State of São Paulo (FAPESP, grant number 2015/21907-0, Brazil) to PAN.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • M. G. Da Broi
    • 1
  • V. S. I. Giorgi
    • 1
  • F. Wang
    • 2
  • D. L. Keefe
    • 2
    • 3
  • D. Albertini
    • 4
  • P. A. Navarro
    • 1
    Email author
  1. 1.Division of Human Reproduction, Department of Gynecology and Obstetrics, Ribeirão Preto School of MedicineUniversity of São PauloRibeirao PretoBrazil
  2. 2.Department of Obstetrics and Gynecology, Laboratory of Reproductive MedicineNYU School of MedicineNew YorkUSA
  3. 3.Department of Obstetrics and GynecologyNew York University, Langone Medical CenterNew YorkUSA
  4. 4.The Center for Human ReproductionNew YorkUSA

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