Journal of Assisted Reproduction and Genetics

, Volume 34, Issue 1, pp 61–70 | Cite as

Effect of body mass index on the outcomes of controlled ovarian hyperstimulation in Chinese women with polycystic ovary syndrome: a multicenter, prospective, observational study

  • Yan Sheng
  • Guangxiu Lu
  • Jiayin Liu
  • Xiaoyan Liang
  • Yanping Ma
  • Xuehong Zhang
  • Songying Zhang
  • Yingpu Sun
  • Yun Sun
  • Wenfeng Chen
  • Wenhui Fang
  • Zijiang ChenEmail author
Assisted Reproduction Technologies



The purpose of the present study is to explore the influence of body mass index (BMI) on outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) techniques in Chinese women with polycystic ovary syndrome (PCOS).


This was a multicenter, prospective, observational study that enrolled 800 subjects with PCOS from nine hospitals in China. Patients were categorized according to BMI categories: underweight, <18.5 kg/m2; normal, 19–23.9 kg/m2; overweight, 24–27.9 kg/m2; and obese, ≥28 kg/m2. Total recombinant follicle-stimulating hormone (rFSH) dose used, estradiol, and progesterone levels on human chorionic gonadotropin (hCG) day; implantation rate; and biochemical, clinical, and ongoing pregnancy rates were compared among BMI categories. Hormone levels (estradiol, follicle-stimulating hormone (FSH), LH, testosterone, and progesterone) were measured using electrochemiluminescence assays.


Among the 774 subjects, 27.3 % were overweight and 8.1 % were obese. The rFSH dose used differed significantly among BMI categories (P < 0.001). The implantation rate was lower in obese subjects than that in normal-weight subjects (25.3 vs 45.7 %). Clinical pregnancy rate per transfer differed among BMI categories (P = 0.033), but there was no difference for biochemical (P = 0.327) and ongoing (P = 0.084) pregnancy rates. The miscarriage rate was similar among BMI categories.


More than one third of Chinese women with PCOS undergoing IVF/ICSI are overweight or obese. Elevated BMI is associated with reduced clinical pregnancy rate but similar ongoing pregnancy rates, suggesting that BMI has little impact on IVF outcomes.


Polycystic ovary syndrome In vitro fertilization Intracytoplasmic sperm injections Body mass index Pregnancy rate 



This study was supported by Merck Serono Co., Ltd. (Grant number EMR700623-530). We thank Wenfeng Chen (principal biostatistician) from Global Biostatistics & Epidemiology, Merck Serono (Beijing) Pharmaceutical R&D Co., Ltd. In addition, we thank all the staffs from research centers for their assistance.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the ethics committees of the participating hospitals.

Informed consent

All study subjects were fully informed as to the nature of the study and provided written consent for inclusion.

Supplementary material

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Table S1 (DOCX 16 kb)
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Table S3 (DOCX 18 kb)
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Table S4 (DOCX 16 kb)
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Table S5 (DOCX 18 kb)
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Table S6 (DOCX 17 kb)


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Yan Sheng
    • 1
  • Guangxiu Lu
    • 2
  • Jiayin Liu
    • 3
  • Xiaoyan Liang
    • 4
  • Yanping Ma
    • 5
  • Xuehong Zhang
    • 6
  • Songying Zhang
    • 7
  • Yingpu Sun
    • 8
  • Yun Sun
    • 9
  • Wenfeng Chen
    • 10
  • Wenhui Fang
    • 10
  • Zijiang Chen
    • 1
    Email author
  1. 1.Center for Reproductive MedicineShandong UniversityJinanChina
  2. 2.Reproductive & Genetic Hospital CITIC-XiangyaChangshaChina
  3. 3.Jiangsu Province HospitalNanjingChina
  4. 4.The Sixth Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina
  5. 5.The First People’s Hospital of Yunnan ProvinceKunmingChina
  6. 6.The First Hospital of Lanzhou UniversityLanzhouChina
  7. 7.Sir Run Run Shaw Hospital, School of MedicineZhejiang UniversityHangzhouChina
  8. 8.The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina
  9. 9.Renji HospitalShanghai Jiaotong University School of MedicineShanghaiChina
  10. 10.Merck Serono Co., LtdBeijingChina

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