Donor TSH level is associated with clinical pregnancy among oocyte donation cycles
- 283 Downloads
The purpose of the study is to evaluate the association between donor TSH level (independent of recipient TSH level) and recipient pregnancy outcome among fresh donor oocyte IVF cycles.
This is a retrospective cohort study investigating 232 consecutive fresh donor-recipient cycles (200 total oocyte donors) at an academic medical center. Main outcome measures include clinical pregnancy and live birth.
Cycles were categorized into two groups based on donor TSH level (< 2.5 and ≥ 2.5 mIU/L). After controlling for multiple donor and recipient characteristics, the probability of clinical pregnancy was significantly lower among donors with TSH levels ≥2.5 mIU/L compared to those with TSH values <2.5 mIU/L (43.1 %, 95 % CI 28.5–58.9, versus 66.7 %, 95 % CI 58.6–73.9, respectively, p = 0.01). The difference in live birth rates between the two groups did not achieve statistical significance (43.1 %, 95 % CI 28.8–58.6, versus 58.0 %, 95 % CI 50.0–65.6, respectively, p = 0.09).
Donor TSH level, independent of recipient TSH level, is associated with recipient clinical pregnancy. These findings suggest that thyroid function may impact the likelihood of pregnancy at the level of the oocyte.
KeywordsThyroid-stimulating hormone Oocyte donation Infertility In vitro fertilization
We would like to express our gratitude to the Deborah Kelly Center for Outcomes Research of the Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital for the generous support of this study.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
- 3.Aghajanova L, Stavreus-Evers A, Lindeberg M, Landgren BM, Sparre LS, Hovatta O. Thyroid-stimulating hormone receptor and thyroid hormone receptors are involved in human endometrial physiology. Fertil Steril. 2011;95(1):230–7. doi: 10.1016/j.fertnstert.2010.06.079. 7 e1-2.CrossRefPubMedGoogle Scholar
- 11.Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinologist. 2012;18(6):988–1028.Google Scholar
- 17.Kim CH, Ahn JW, Kang SP, Kim SH, Chae HD, Kang BM. Effect of levothyroxine treatment on in vitro fertilization and pregnancy outcome in infertile women with subclinical hypothyroidism undergoing in vitro fertilization/intracytoplasmic sperm injection. Fertil Steril. 2011;95(5):1650–4. doi: 10.1016/j.fertnstert.2010.12.004.CrossRefPubMedGoogle Scholar