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Journal of Assisted Reproduction and Genetics

, Volume 32, Issue 12, pp 1811–1815 | Cite as

Irregular cleavage of early preimplantation human embryos: characteristics of patients and pregnancy outcomes

  • Miriam AlmagorEmail author
  • Yuval Or
  • Sheila Fieldust
  • Zeev Shoham
Embryo Biology

Abstract

Purpose

This is a retrospective analysis of the morphokinetics, prevalence, and implantation potential of embryos with irregular first and second cleavages as identified by time-lapse microscopy.

Methods

The study included 253 women who underwent 387 assisted reproduction treatments with intracytoplasmic sperm injection (ICSI). Each patient was assigned to one of three groups based on embryo cleavage results. In group I, one to two embryos per cycle showed irregular cleavage; group II, at least three embryos with abnormal cleavage; and in group III (the control group), all embryos cleaved normally. The number of embryos that cleaved from 1 to ≥3 cells or from 2 to ≥5 cells for each patient was recorded. Their prevalence and association with women’s characteristics and pregnancy outcome were evaluated.

Results

The prevalence of irregular cleavage was 15.6 % among 1772 ICSI embryos. In 101 cycles, 1–2 embryos per cycle showed irregular cleavage (group I). In 32 cycles, at least 3 embryos showed abnormal cleavage (group II). In 254 cycles, all embryos cleaved normally (group III). The average age of the women in group II was significantly lower in comparison with groups I and III (32.5 ± 4.2 vs. 35.1 ± 4.9 and 35.5 ± 5.1, respectively, p < 0.02). In comparison of groups I and II, the odds ratio for ≥3 embryos with irregular cleavage in women younger than 35 was 3.48 (95 % CI, 1.28 to 9.46). Embryos with irregular cleavage were transferred in 16 women. Three live births were achieved following the transfer of single blastocysts derived from embryos with irregular cleavage from two to five cells.

Conclusions

Early embryos with irregular cleavage are significantly more prevalent in younger women. When these embryos develop to the blastocyst stage, they may have normal implantation potential, leading to the birth of healthy babies.

Keywords

Embryo development Implantation Irregular cleavage Pregnancy Time-lapse 

Notes

Funding

None.

Conflict of interest

The authors declare that they have no competing interests.

Ethics approval

Study approval was obtained from the Kaplan Medical Center Institutional Review Board.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Miriam Almagor
    • 1
    • 2
    Email author
  • Yuval Or
    • 1
  • Sheila Fieldust
    • 1
  • Zeev Shoham
    • 1
  1. 1.Reproductive Medicine and IVF UnitKaplan Medical Center, Rehovot, Israel, affiliated with the Hadassah Medical School, the Hebrew UniversityJerusalemIsrael
  2. 2.Department of Obstetrics and Gynecology, Reproductive Medicine and IVF UnitKaplan Medical CenterRehovotIsrael

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