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Blood type predicts live birth in the infertile population

  • Assisted Reproduction Technologies
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Abstract

Purpose

To determine if blood type in infertile women relates to the likelihood for live birth (LB) following IVF, and to the etiology for infertility.

Methods

Retrospective study of patients undergoing IVF at two academic centers in the northeast US. Relationships between blood type (A, B, AB, O) and patient characteristics, IVF cycle parameters and LB were assessed utilizing multivariable logistic regression analyses.

Results

In the studied population (n = 626), women with type O were significantly more likely to have baseline FSH > 10 IU/L after adjusting for age, BMI and race (OR 5.09, 95 % CI 1.4–18.7, p = 0.01). Conversely, women with blood type A were significantly more likely to have ovulatory infertility compared to those with blood type O after adjusting for age and BMI (OR 3.2, 95 % CI 1.7–6.2). Blood type B was associated with increased likelihood of live birth (OR 1.9, 95 % CI 1.10–3.41, p = 0.03) after adjusting for factors recognized to impact IVF outcome.

Conclusion

Ovulatory infertility and baseline FSH > 10 IU/L were more prevalent in women with blood type A and O respectively. However, those of blood type B had significantly higher odds for LB compared to other blood types after adjusting for factors recognized to impact on IVF cycle outcome. While underlying mechanisms are unclear, for infertile women, patient’s blood type is seemingly relevant for IVF cycle outcome.

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Acknowledgment

The authors would like to thank Edward Nejat.

Study funding

None.

Conflict of interest

None of the authors has any conflict of interest to declare.

Author information

Authors and Affiliations

  1. Reproductive Endocrinology and Infertility, Department Obstetrics, Gynecology and Women’s Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    Michelle Goldsammler & Sangita K. Jindal

  2. Reproductive Endocrinology and Infertility, Department Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar St, New Haven, CT, 06510, USA

    Amanda Kallen, Natu Mmbaga & Lubna Pal

  3. Montefiore’s Institute for Reproductive Medicine and Health, 141 South Central Avenue, Suite 201, Hartsdale, NY, 10530, USA

    Sangita K. Jindal

Authors
  1. Michelle Goldsammler
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  2. Sangita K. Jindal
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  3. Amanda Kallen
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  4. Natu Mmbaga
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  5. Lubna Pal
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Corresponding author

Correspondence to Sangita K. Jindal.

Additional information

Capsule In an infertile population, we observed that blood type B was associated with increased likelihood of live birth.

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Goldsammler, M., Jindal, S.K., Kallen, A. et al. Blood type predicts live birth in the infertile population. J Assist Reprod Genet 32, 551–555 (2015). https://doi.org/10.1007/s10815-015-0441-2

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  • DOI: https://doi.org/10.1007/s10815-015-0441-2

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