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Journal of Assisted Reproduction and Genetics

, Volume 31, Issue 11, pp 1557–1564 | Cite as

Treatment history and outcome of 24 deliveries worldwide after autotransplantation of cryopreserved ovarian tissue, including two new Danish deliveries years after autotransplantation

  • Kirsten T MacklonEmail author
  • Annette Klüver Jensen
  • Anne Loft
  • Erik Ernst
  • Claus Yding Andersen
Fertility Preservation

Abstract

Purpose

To report another two successful pregnancies and deliveries resulting from autotransplanted cryopreserved ovarian tissue several years after the autotransplantation procedure took place. Further, to review the literature on the treatment history, number of live births and their outcome so far reported worldwide.

Methods

Two women underwent fertility preservation with cryopreservation of their ovarian tissue prior to a potentially sterilizing treatment with bone marrow transplantation. One woman suffered from paroxystic nocturnal hemoglobinuria and one woman from relapse of Hodgkin′s lymphoma. Both suffered from premature ovarian insufficiency after treatment. Because of a pregnancy wish they later had pieces of thawed cortical tissue transplanted to the remaining ovary and the anterior abdominal wall. PubMed was searched for reports of deliveries resulting from cryopreserved ovarian tissue in peer-reviewed papers.

Results

Five years after the autotransplantation the first patient became spontaneously pregnant and delivered a healthy baby boy at term. The second patient became pregnant after undergoing one cycle of in vitro fertilisation five years after the autotransplantation. She delivered a healthy baby boy at gestational week 36. Twenty healthy singletons and two sets of twins have been born according to peer-reviewed publications.

Conclusion

Contrary to most of the published deliveries our latest two cases occurred several years after the autotransplantation procedure took place. This proves that ovarian grafts are capable of functioning for several years after the autotransplantation has occurred. Today, a total of 26 healthy children have been born as a result of cryopreservation of ovarian tissue.

Keywords

cryopreservation deliveries fertility preservation ovary ovarian tissue 

References

  1. 1.
    Schmidt KT, Rosendahl M, Ernst E, Loft A, Andersen AN, Dueholm M, et al. Autotransplantation of cryopreserved ovarian tissue in 12 women with chemotherapy-induced premature ovarian failure: the Danish experience. Fertil Steril. 2011;95:695–701.PubMedCrossRefGoogle Scholar
  2. 2.
    Donnez J, Dolmans MM, Pellicer A, Diaz-Garcia C, Serrano MS, Schmidt KT, et al. Restoration of ovarian activity and pregnancy after transplantation of cryopreserved ovarian tissue: a review of 60 cases of reimplantation. Fertil Steril. 2013;99:1503–13.PubMedCrossRefGoogle Scholar
  3. 3.
    Meirow D. Reproduction post-chemotherapy in young cancer patients. Mol Cell Endocrinol. 2000;169:123–31.PubMedCrossRefGoogle Scholar
  4. 4.
    Greve T, Schmidt KT, Kristensen SG, Andersen CY. Evaluation of the ovarian reserve in women transplanted with frozen and thawed ovarian cortical tissue. Fertil Steril. 2012;97:1394–8.PubMedCrossRefGoogle Scholar
  5. 5.
    Andersen CY, Silber SJ, Berghold SH, Jørgensen JS, Ernst E. Long-term duration of function of ovarian tissue transplants: case reports. Reprod BioMed Online. 2012;25:128–32.PubMedCrossRefGoogle Scholar
  6. 6.
    Kim SS. Assessment of long term endocrine function after transplantation of frozen-thawed human ovarian tissue to the heterotopic site: 10 year longitudinal follow-up study. J Assist Reprod Genet. 2012;29:489–93.PubMedCentralPubMedCrossRefGoogle Scholar
  7. 7.
    Schmidt KLT, Byskov AG, Andersen AN, Muller J, Andersen CY. Density and distribution of primordial follicles in single pieces of cortex from three entire human ovaries. Hum Reprod. 2003;18:1158–64.PubMedCrossRefGoogle Scholar
  8. 8.
    Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364:1405–10.PubMedCrossRefGoogle Scholar
  9. 9.
    Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. N Engl J Med. 2005;353:318–21.PubMedCrossRefGoogle Scholar
  10. 10.
    Demeestere I, Simon P, Emiliani S, Delbaere A, Englert Y. Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin′s disease. Oncologist. 2007;12:1437–42.PubMedCrossRefGoogle Scholar
  11. 11.
    Demeestere I, Simon P, Moffa F, Delbaere A, Englert Y. Birth of a second healthy girl more than 3 years after cryopreserved ovarian graft. Hum Reprod. 2010;25:1590–1.PubMedCrossRefGoogle Scholar
  12. 12.
    Andersen CY, Rosendahl M, Byskov AG, Loft A, Ottosen C, Dueholm M, et al. Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue, 23. Oxford, England: Human reproduction; 2008. p. 2266–72.Google Scholar
  13. 13.
    Ernst E, Bergholdt S, Jorgensen JS, Andersen CY. The first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue, 25. Oxford, England: Human reproduction; 2010. p. 1280–1.Google Scholar
  14. 14.
    Andersen CY, Silber SJ, Bergholdt SH, Jorgensen JS, Ernst E. Long-term duration of function of ovarian tissue transplants: case reports. Reprod BioMed Online. 2012;25:128–32.PubMedCrossRefGoogle Scholar
  15. 15.
    Roux C, Amiot C, Agnani G, Aubard Y, Rohrlich PS, Piver P. Live birth after ovarian tissue autograft in a patient with sickle cell disease treated by allogeneic bone marrow transplantation. Fertil Steril. 2010;93(2413):e15–9.PubMedGoogle Scholar
  16. 16.
    Silber S, Kagawa N, Kuwayama M, Gosden R. Duration of fertility after fresh and frozen ovary transplantation. Fertil Steril. 2010;94:2191–6.PubMedCrossRefGoogle Scholar
  17. 17.
    Silber SJ, DeRosa M, Pineda J, Lenahan K, Grenia D, Gorman K, et al. A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation, 23. Oxford, England: Human reproduction; 2008. p. 1531–7.Google Scholar
  18. 18.
    Sanchez-Serrano M, Crespo J, Mirabet V, Cobo AC, Escriba MJ, Simon C, et al. Twins born after transplantation of ovarian cortical tissue and oocyte vitrification. Fertil Steril. 2010;93(268):e11–3.PubMedGoogle Scholar
  19. 19.
    Donnez J, Squifflet J, Jadoul P, Demylle D, Cheron AC, Van Langendonckt A, et al. Pregnancy and live birth after autotransplantation of frozen-thawed ovarian tissue in a patient with metastatic disease undergoing chemotherapy and hematopoietic stem cell transplantation. Fertil Steril. 2011;95:e1–4.CrossRefGoogle Scholar
  20. 20.
    Revel A, Laufer N, Ben Meir A, Lebovich M, Mitrani E. Micro-organ ovarian transplantation enables pregnancy: a case report, 26. Oxford, England: Human reproduction; 2011. p. 1097–103.Google Scholar
  21. 21.
    Donnez J, Silber S, Andersen CY, Demeestere I, Piver P, Meirow D, et al. Children born after autotransplantation of cryopreserved ovarian tissue. a review of 13 live births. Ann Med. 2011;43:437–50.PubMedCrossRefGoogle Scholar
  22. 22.
    Donnez J, Jadoul P, Pirard C, Hutchings G, Demylle D, Squifflet J, et al. Live birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease. Fertil Steril. 2012;98:720–5.PubMedCrossRefGoogle Scholar
  23. 23.
    Dittrich R, Lotz L, Keck G, Hoffmann I, Mueller A, Beckmann MW, et al. Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation. Fertil Steril. 2012;97:387–90.PubMedCrossRefGoogle Scholar
  24. 24.
    Kawamura K, Cheng Y, Suzuki N, Deguchi M, Sato Y, Takae S, et al. Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment. Proc Natl Acad Sci U S A. 2013;110:17474–9.PubMedCentralPubMedCrossRefGoogle Scholar
  25. 25.
    Revelli A, Marchino G, Dolfin E, Molinari E, Delle Piane L, Salvagno F, et al. Live birth after orthotopic grafting of autologous cryopreserved ovarian tissue and spontaneous conception in Italy. Fertil Steril. 2013;99:227–30.PubMedCrossRefGoogle Scholar
  26. 26.
    Stern CJ, Gook D, Hale LG, Agresta F, Oldham J, Rozen G, et al. First reported clinical pregnancy following heterotopic grafting of cryopreserved ovarian tissue in a woman after a bilateral oophorectomy, 28. Oxford, England: Human reproduction; 2013. p. 2996–9.Google Scholar
  27. 27.
    Callejo J, Salvador C, Gonzalez-Nunez S, Almeida L, Rodriguez L, Marques L, et al. Live birth in a woman without ovaries after autograft of frozen-thawed ovarian tissue combined with growth factors. Journal of ovarian research. 2013;6:33.PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Kirsten T Macklon
    • 1
    Email author
  • Annette Klüver Jensen
    • 2
  • Anne Loft
    • 1
  • Erik Ernst
    • 3
  • Claus Yding Andersen
    • 2
  1. 1.The Fertility ClinicUniversity Hospital of CopenhagenCopenhagenDenmark
  2. 2.The Laboratory of Reproductive BiologyUniversity Hospital of CopenhagenCopenhagenDenmark
  3. 3.The Fertility ClinicUniversity Hospital of AarhusAarhusDenmark

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