Journal of Assisted Reproduction and Genetics

, Volume 31, Issue 10, pp 1397–1400 | Cite as

Live birth after 6 years of oocyte vitrification in a survivor with breast cancer

  • Eduardo Leme Alves da MottaEmail author
  • Monique Bonavita
  • José Roberto Alegretti
  • Maurício Chehin
  • Paulo Serafini
Fertility Preservation


Because of scientific developments, life has been extended in recent decades, and among all diseases, cancer has gained a greater dimension and is recognized as a public health topic worldwide. There has been a major focus on breast cancer, which is recognized as the most common malignancy in women [1].

In 2012, there were an estimated 230,000 new cases of invasive breast cancer in the USA, mainly after menopause [2]. However, breast cancer at the reproductive age is considered a worst and invasive prognosis, for which chemotherapy using high doses of alkylating agents and radiotherapy with ionizing radiation should be applied. Such approach is known to reduce the primordial follicle reserve and cause premature ovarian failure, possibly with genetic damage to growing eggs [3].

Advances in reproductive techniques have provided many fertility preservation options [4]. However, initial trials on oocyte cryopreservation were limited by spindle misalignment and errors in the...


Ovarian Reserve Fertility Preservation Premature Ovarian Failure Antral Follicle Count Oocyte Cryopreservation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Eduardo Leme Alves da Motta
    • 1
    • 2
    • 3
    Email author
  • Monique Bonavita
    • 2
  • José Roberto Alegretti
    • 1
  • Maurício Chehin
    • 1
  • Paulo Serafini
    • 1
    • 2
    • 4
  1. 1.Huntington Reproductive MedicineSão PauloBrazil
  2. 2.Centre of Human ReproductionHospital e Maternidade Santa JoanaSão PauloBrazil
  3. 3.Gynecology Department of Paulista School of MedicineFederal University of Sao Paulo (EPM-UNIFESP)Sao PauloBrazil
  4. 4.Gynecology Discipline of School of MedicineUniversity of Sao Paulo (USP)Sao PauloBrazil

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