Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs

  • Mehmet B. Cetinkaya
  • Linda J. Siano
  • Claudio Benadiva
  • Denny Sakkas
  • Pasquale Patrizio



The aim of this study was to analyze the outcomes of IVF/ICSI cycles in women aged 43 and beyond.


Retrospective analysis of clinical pregnancy and live birth rates in168 fresh, non donor, ART cycles performed in two Connecticut university IVF programs.


In women of 43 and 44 years the overall clinical pregnancy and live birth rates were 8.3 % and 5.3 % per initiated cycle, respectively. There were no clinical pregnancies in women ≥45 years old. First cycle characteristics were not different from repeated cycles in terms of duration of ovulation induction, number of collected oocytes and transferred embryos (p > 0.05).


Pregnancies can still be achieved with IVF/ICSI up to the age of 44. Since most pregnancies occurred within the first 3 cycles, another attempt may be a reasonable option before resorting to oocyte donation for patients who failed two previous cycles. Women 45 years and beyond do not benefit from ART procedures using their own oocytes.


IVF ICSI Advanced age Pregnancy success 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Mehmet B. Cetinkaya
    • 1
    • 2
  • Linda J. Siano
    • 3
  • Claudio Benadiva
    • 3
  • Denny Sakkas
    • 1
  • Pasquale Patrizio
    • 1
  1. 1.Obstetrics, Gynecology and Reproductive SciencesYale University Fertility CenterNew HavenUSA
  2. 2.School of Medicine, Departments of Obstetrics and GynecologyUniversity of Ondokuz MayısSamsunTurkey
  3. 3.Center for Advanced Reproductive ServicesUniversity of Connecticut Health CenterFarmingtonUSA

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