Journal of Assisted Reproduction and Genetics

, Volume 30, Issue 4, pp 479–485 | Cite as

Sperm selection using magnetic activated cell sorting (MACS) in assisted reproduction: a systematic review and meta-analysis

  • Monica GilEmail author
  • Valerie Sar-Shalom
  • Yolisid Melendez Sivira
  • Ramon Carreras
  • Miguel Angel Checa
Technological Innovations



To determine whether the use of Magnetic Activated Cell Sorting (MACS) as a sperm selection technique improves ART success rates in couples undergoing assisted reproduction treatment.


Systematic review and meta-analysis of prospective randomized trials. Two reviewers conducted study selection and data extraction independently.


Five studies (prospective randomized trials) that comprised 499 patients were included. Sperm selection using MACS resulted in statistically significant differences in pregnancy rates when compared with density gradient centrifugation and swim-up techniques (RR = 1.50, 95 % CI 1.14–1.98). No differences were found between the groups according to the implantation (RR = 1.03, 95 % CI 0.80–1.31) and miscarriage (RR = 2.00, 95 % CI 0.19–20.90) rates.


MACS appears to be a safe and efficient method to select functional sperm with consistently good results. This technique may improve pregnancy rates when used to complement standard sperm selection methods in ART.


MACS Sperm selection Annexin V Pregnancy DNA fragmentation Meta-analysis 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Monica Gil
    • 1
    Email author
  • Valerie Sar-Shalom
    • 1
  • Yolisid Melendez Sivira
    • 1
  • Ramon Carreras
    • 2
  • Miguel Angel Checa
    • 2
  1. 1.Hospital Universitari del Mar: International Master in Reproductive MedicineAutonomous University of BarcelonaBarcelonaSpain
  2. 2.Department of Obstetrics and Gynecology, Hospital Universitari del MarAutonomous University of BarcelonaBarcelonaSpain

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