Journal of Assisted Reproduction and Genetics

, Volume 30, Issue 3, pp 305–314 | Cite as

A review of 15 years of ovarian tissue bank activities

  • Marie-Madeleine Dolmans
  • Pascale Jadoul
  • Sébastien Gilliaux
  • Christiani A. Amorim
  • Valérie Luyckx
  • Jean Squifflet
  • Jacques Donnez
  • Anne Van Langendonckt
Fertility Preservation

Abstract

Purpose

To review 15 years of activities in ovarian tissue cryobanking from medical database files, including patient indications, histological evaluation and clinical characteristics.

Methods

Retrospective longitudinal analysis of data from an ovarian tissue bank in an academic hospital. Five hundred and eighty-two patients had their ovarian tissue cryobanked between April 1997 and January 2012. Analysis of cryobanking database: precryopreservation patient characteristics, indications and safety issues, laboratory files and postcryopreservation clinical data.

Results

Of the 582 patients who had their ovarian tissue cryopreserved, 106 patients donated for research purposes and 476 patients for fertility preservation and long-term cryopreservation. Clinical data analysis of the 476 patients revealed a mean age at the time of cryopreservation of 23 ± 8.5 years (range: 9 months – 39 years), with 96.2 % of subjects aged ≤35 years (n = 458). Among 391 cases of malignant disease, hematological malignancies (39.9 %, n = 156) and breast cancer (21.7 %, n = 85) were the two main indications. At histology, malignant cells were found in ovarian tissue from leukemia patients (n = 3) and non-Hodgkin’s lymphoma patients (n = 2). Eleven patients underwent autotransplantation, resulting in 5 live births and 1 ongoing pregnancy.

Conclusion

This is the largest and most comprehensive study to describe and analyze indications and clinical patient characteristics before and after ovarian tissue cryopreservation. The procedure is safe, easy and promising. The database concept is a useful tool in patient selection for autotransplantation.

Keywords

Chemotherapy Cancer Premature ovarian failure Ovarian tissue cryopreservation Database Malignant cells Cryobank 

References

  1. 1.
    Abir R, Feinmesser M, Yaniv I, Fisch B, Cohen IJ, Ben-Haroush A, et al. Occasional involvement of the ovary in Ewing sarcoma. Hum Reprod. 2010;25:1708–12.PubMedCrossRefGoogle Scholar
  2. 2.
    Amorim CA. Artificial ovary. In: Donnez J, Kim SS, editors. Principles and practice of fertility preservation. First Editionth ed. Cambridge: Cambridge University Press; 2011. p. 448–58.CrossRefGoogle Scholar
  3. 3.
    Amorim CA, Curaba M, Van Langendonckt A, Dolmans MM, Donnez J. Vitrification as an alternative means of cryopreserving ovarian tissue. Reprod Biomed Online. 2011;23:160–86.PubMedCrossRefGoogle Scholar
  4. 4.
    Andersen CY, Rosendahl M, Byskov AG, Loft A, Ottosen C, Dueholm M, et al. Two successful pregnancies following autotransplantation of frozen/thawed ovarian tissue. Hum Reprod. 2008;23:2266–72.PubMedCrossRefGoogle Scholar
  5. 5.
    Borgström B, Hreinsson J, Rasmussen C, Sheikhi M, Fried G, Keros V, et al. Fertility preservation in girls with turner syndrome: prognostic signs of the presence of ovarian follicles. J Clin Endocrinol Metab. 2009;94(1):74–80.PubMedGoogle Scholar
  6. 6.
    Brizek CL, Schlaff S, Pellegrini VA, Frank JB, Worrilow KC. Increased incidence of aberrant morphological phenotypes in human embryogenesis– an association with endometriosis. J Assist Reprod Genet. 1995;12:106–12.PubMedCrossRefGoogle Scholar
  7. 7.
    Dath C, Van Eyck AS, Dolmans MM, Romeu L, Delle Vigne L, Donnez J, et al. Xenotransplantation of human ovarian tissue to nude mice: comparison between four grafting sites. Hum Reprod. 2010;25:1734–43.PubMedCrossRefGoogle Scholar
  8. 8.
    Demeestere I, Simon P, Emiliani S, Delbaere A, Englert Y. Fertility preservation: successful transplantation of cryopreserved ovarian tissue in a young patient previously treated for Hodgkin’s disease. Oncologist. 2007;12:1437–42.PubMedCrossRefGoogle Scholar
  9. 9.
    Demeestere I, Simon P, Emiliani S, Delbaere A, Englert Y. Orthotopic and heterotopic ovarian tissue transplantation. Hum Reprod Update. 2009;15:649–65.PubMedCrossRefGoogle Scholar
  10. 10.
    Dittrich R, Lotz L, Keck G, Hoffmann I, Mueller A, Beckmann MW, et al. Live birth after ovarian tissue autotransplantation following overnight transportation before cryopreservation. Fertil Steril. 2012;97:387–90.PubMedCrossRefGoogle Scholar
  11. 11.
    Dolmans MM, Demylle D, Martinez-Madrid B, Donnez J. Efficacy of in vitro fertilization after chemotherapy. Fertil Steril. 2005;83:897–901.PubMedCrossRefGoogle Scholar
  12. 12.
    Dolmans MM, Yuan WY, Camboni A, Torre A, Van Langendonckt A, Martinez-Madrid B, et al. Development of antral follicles after xenografting of isolated small human preantral follicles. Reprod Biomed Online. 2008;16:705–11.PubMedCrossRefGoogle Scholar
  13. 13.
    Dolmans MM, Marinescu C, Saussoy P, Van Langendonckt A, Amorim C, Donnez J. Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe. Blood. 2010;116:2908–14.PubMedCrossRefGoogle Scholar
  14. 14.
    Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, et al. Livebirth after orthotopic transplantation of cryopreserved ovarian tissue. Lancet. 2004;364:1405–10.PubMedCrossRefGoogle Scholar
  15. 15.
    Donnez J, Martinez-Madrid B, Jadoul P, Van Langendonckt A, Demylle D, Dolmans MM. Ovarian tissue cryopreservation and transplantation: a review. Hum Reprod Update. 2006;12:519–35.PubMedCrossRefGoogle Scholar
  16. 16.
    Donnez J, Dolmans MM, Demylle D, Jadoul P, Pirard C, Squifflet J, et al. Restoration of ovarian function after orthotopic (intraovarian and periovarian) transplantation of cryopreserved ovarian tissue in a woman treated by bone marrrow transplantation for sickle cell anaemia: case report. Hum Reprod. 2006;21:183–8.PubMedCrossRefGoogle Scholar
  17. 17.
    Donnez J, Squifflet J, Van Eyck AS, Demylle D, Jadoul P, Van Langendonckt A, et al. Restoration of ovarian function in orthotopically transplanted cryopreserved ovarian tissue: a pilot experience. Reprod Biomed Online. 2008;16:694–704.PubMedCrossRefGoogle Scholar
  18. 18.
    Donnez J, Jadoul P, Donnez O, Squifflet J, Gilliaux S, Dolmans M-M. How to preserve fertility before chemotherapy. BJMO. 2009;3:7–15.Google Scholar
  19. 19.
    Donnez J, Silber S, Andersen CY, Demeestere I, Piver P, Meirow D, et al. Children born after autotransplantation of cryopreserved ovarian tissue. A review of 13 live births. Ann Med. 2011;43:437–50.PubMedCrossRefGoogle Scholar
  20. 20.
    Donnez J, Jadoul P, Pirard C, Hutchings G, Demylle D, Squifflet J, et al. Live birth after transplantation of frozen-thawed ovarian tissue after bilateral oophorectomy for benign disease. Fertil Steril. 2012;98:720–5.PubMedCrossRefGoogle Scholar
  21. 21.
    Ernst E, Bergholdt S, Jorgensen JS, Andersen CA. The first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue. Hum Reprod. 2010;25:1280–1.PubMedCrossRefGoogle Scholar
  22. 22.
    Feigin E, Abir R, Fisch B, Kravarusic D, Steinberg R, Nitke S, et al. Laparoscopic ovarian tissue preservation in young patients at risk for ovarian failure as a result of chemotherapy/irradiation for primary malignancy. J Pediatr Surg. 2007;42:862–4.PubMedCrossRefGoogle Scholar
  23. 23.
    Gook DA, Edgar DH, Borg J, Archer J, McBain JC. Diagnostic assessment of the developmental potential of human cryopreserved ovarian tissue from multiple patients using xenografting. Hum Reprod. 2005;20:72–8.PubMedCrossRefGoogle Scholar
  24. 24.
    Gosden RG, Baird DT, Wade JC, Webb R. Restoration of fertility to oophorectomized sheep by ovarian autografts stored at −196 °C. Hum Reprod. 1994;9:597–603.PubMedGoogle Scholar
  25. 25.
    Jadoul P, Dolmans MM, Donnez J. Fertility preservation in girls during childhood: is it feasible, efficient and safe and to whom should it be proposed? Hum Reprod Update. 2010;16:617–30.PubMedCrossRefGoogle Scholar
  26. 26.
    Jadoul P, Anckaert E, Dewandeleer A, Steffens M, Dolmans MM, Vermylen C, et al. Clinical and biologic evaluation of ovarian function in women treated by bone marrow transplantation for various indications during childhood or adolescence. Fertil Steril. 2011;96(1):126–33.PubMedCrossRefGoogle Scholar
  27. 27.
    Janse F, Donnez J, Anckaert E, de Jong FH, Fauser B, Dolmans MM. Limited value of ovarian function markers after orthotopic transplantation of ovarian tissue after gonadotoxic treatment. J Clin Endocrinol Metab. 2011;96:1136–44.PubMedCrossRefGoogle Scholar
  28. 28.
    Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics. Cancer J Clin. 2009;59:225–49.CrossRefGoogle Scholar
  29. 29.
    Kitajima M, Defrère S, Dolmans MM, Colette S, Squifflet J, Van Langendonckt A, et al. Endometriomas as a possible cause of reduced ovarian reserve in women with endometriosis. Fertil Steril. 2011;96:685–91.PubMedCrossRefGoogle Scholar
  30. 30.
    Larsen EC, Muller J, Schmiegelow K, Rechnitzer C, Andersen AN. Reduced ovarian function in long-term survivors of radiation- and chemotherapy-treated childhood cancer. J Clin Endocrinol Metab. 2003;88:5307–14.PubMedCrossRefGoogle Scholar
  31. 31.
    Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, et al. American society of clinical oncology. American society of clinical oncology recommendations on fertility preservation in cancer patients. J Clin Oncol. 2006;24:2917–31.PubMedCrossRefGoogle Scholar
  32. 32.
    Mayerhofer K, Ott J, Nouri K, Stoegbauer L, Fischer EM, Lipovac M, et al. Laparoscopic ovarian tissue harvesting for cryopreservation: an effective and safe procedure for fertility preservation. Eur J Obstet Gynecol Reprod Biol. 2010;152:68–72.PubMedCrossRefGoogle Scholar
  33. 33.
    Meirow D, Baum M, Rabinovici Y, Levron J, Hardan I, Schiff E, et al. Ovarian tissue cryopreservation in hematologic malignancy: 10 year’s experience. Leuk Lymphoma. 2007;48:1569–76.PubMedCrossRefGoogle Scholar
  34. 34.
    Meirow D, Hardan I, Dor J, Fridman E, Elizur S, Ra’anani H, et al. Searching for evidence of disease and malignant cell contamination in ovarian tissue stored from hematologic cancer patients. Hum Reprod. 2008;23:1007–13.PubMedCrossRefGoogle Scholar
  35. 35.
    Meirow D, Levron J, Eldar-Geva T, Hardan I, Fridman E, Zalel Y, et al. Pregnancy after transplantation of cryopreserved ovarian tissue in a patient with ovarian failure after chemotherapy. NEJM. 2005;353:318–21.PubMedCrossRefGoogle Scholar
  36. 36.
    Meirow D, Lewis H, Nugent D, Epstein M. Subclinical depletion of primordial follicular reserve in mice treated with Cyclophosphamide: clinical importance and proposed accurate investigative tool. Hum Reprod. 1999;14:1903–7.PubMedCrossRefGoogle Scholar
  37. 37.
    Michaeli J, Weintraub M, Gross E, Ginosar Y, Ravitsky V, Eizenman E, et al. Fertility preservation in girls. Obstet Gynecol Int. 2012;139193:1–10.CrossRefGoogle Scholar
  38. 38.
    Nisolle M, Casanas-Roux F, Qu J, Motta P, Donnez J. Histologic and ultrastructural evaluation of fresh and frozen-thawed human ovarian xenografts in nude mice. Fertil Steril. 2000;74:122–9.PubMedCrossRefGoogle Scholar
  39. 39.
    Oktay K, Oktem O. Ovarian cryopreservation and transplantation for fertility preservation for medical indications: report of an ongoing experience. Fertil Steril. 2010;93:762–8.PubMedCrossRefGoogle Scholar
  40. 40.
    Peretz NM, Goldberg H, Kuten A, Meller I, Krivoi E, Lorber A, et al. Long-term sequelae of malignant tumors in childhood: consequences of late side-effects. Harefuah. 2001;140:95–100.PubMedGoogle Scholar
  41. 41.
    Piver P, Amiot C, Agnani G, Pech J, Rohrlich PS, Vidal E, Aubard Y, Roux C (2009) Two pregnancies obtained after a new technique of autotransplantation of cryopreserved ovarian tissue. In: 25th Annual Meeting of ESHRE, 28 June–1 July, 2009. Amsterdam, the Netherlands: Oxford University Press, Hum Reprod i15.Google Scholar
  42. 42.
    Poirot C, Brugières C, Genestie HM. Ovarian tissue cryopreservation for prepubertal girls: indications and feasibility. Gynécol Obstét Fertil. 2005;33:799–803.PubMedCrossRefGoogle Scholar
  43. 43.
    Qu J, Godin PA, Nisolle M, Donnez J. Distribution and epidermal growth factor receptor expression of primordial follicles in human ovarian tissue before and after cryopreservation. Hum Reprod. 2000;15:302–10.PubMedCrossRefGoogle Scholar
  44. 44.
    Revel A, Laufer N, Ben Meir A, Lebovich M, Mitrani E. Micro-organ ovarian transplantation enables pregnancy: a case report. Hum Reprod. 2011;26:1097–10103.PubMedCrossRefGoogle Scholar
  45. 45.
    Revelli A, Marchino G, Dolfin E, Molinari E, Delle Piane L, Salvagno F, et al. Live birth after orthotopic grafting of autologous cryopreserved ovarian tissue and spontaneous conception in Italy. Fertil Steril. 2012;S0015–0282(12):02248.Google Scholar
  46. 46.
    Rosendahl M, Schmidt KT, Ernst E, Rasmussen PE, Loft A, Byskov AG, et al. Cryopreservation of ovarian tissue for a decade in Denmark: a view of the technique. Reprod Biomed Online. 2011;22:162–71.PubMedCrossRefGoogle Scholar
  47. 47.
    Rosendahl M, Timmermans Wielenga V, Nedergaard L, Kristensen SG, Ernst E, Rasmussen PE, et al. Cryopreservation of ovarian tissue for fertility preservation: no evidence of malignant cell contamination in ovarian tissue from patients with breast cancer. Fertil Steril. 2011;95:2158–61.PubMedCrossRefGoogle Scholar
  48. 48.
    Roux C, Amiot C, Agnani G, Aubard Y, Rohrlich PS, Piver P. Live birth after ovarian tissue autograft in a patient with sickle cell disease treated by allogeneic bone marrow transplantation. Fertil Steril. 2010;93:2413.e15–9.CrossRefGoogle Scholar
  49. 49.
    Salooja N, Szydlo RM, Socie G, Rio B, Chatterjee R, Ljungman P, et al. Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet. 2001;358:271–6.PubMedCrossRefGoogle Scholar
  50. 50.
    Sánchez M, Novella-Maestre E, Teruel J, Ortiz E, Pellicer A. The Valencia Programme for Fertility Preservation. Clin Transl Oncol. 2008;10:433–8.PubMedCrossRefGoogle Scholar
  51. 51.
    Sánchez-Serrano M, Crespo J, Mirabet V, Cobo AC, Escribá MJ, Simón C, et al. Twins born after transplantation of ovarian cortical tissue and oocyte vitrification. Fertil Steril. 2010;93:268.e11–3.CrossRefGoogle Scholar
  52. 52.
    Sánchez-Serrano M, Novella-Maestre E, Rosello-Sastre E, Camarasa N, Teruel J, Pellicer A. Malignant cells are not found in ovarian cortex from breast cancer patients undergoing ovarian cortex cryopreservation. Human Reprod. 2009;24:2238–43.CrossRefGoogle Scholar
  53. 53.
    Schmidt KL, Byskov AG, Nyboe Andersen A, Müller J, Yding Andersen C. Density and distribution of primordial follicles in single pieces of cortex from 21 patients and in individual pieces of cortex from three entire human ovaries. Hum Reprod. 2003;18:1158–64.PubMedCrossRefGoogle Scholar
  54. 54.
    Shebl O, Ebner T, Sir A, Schreier-Lechner E, Mayer RB, Tews G, et al. Age-related distribution of basal serum AMH level in women of reproductive age and a presumably healthy cohort. Fertil Steril. 2011;95:832–4.PubMedCrossRefGoogle Scholar
  55. 55.
    Shebl O, Ebner T, Sommergruber M, Sir A, Tews G. Anti muellerian hormone serum levels in women with endometriosis: a case–control study. Gynecol Endocrinol. 2009;25:713–6.PubMedCrossRefGoogle Scholar
  56. 56.
    Silber S, Kagawa N, Kuwayama M, Gosden R. Duration of fertility after fresh and frozen ovary transplantation. Fertil Steril. 2010;94:2191–6.PubMedCrossRefGoogle Scholar
  57. 57.
    Silber SJ, DeRosa M, Pineda J, Lenahan K, Grenia D, Gorman K, et al. A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation. Hum Reprod. 2008;23:1531–7.PubMedCrossRefGoogle Scholar
  58. 58.
    Silber SJ, Lenahan KM, Levine DJ, Pineda JA, Gorman KS, Friez MJ, et al. Ovarian transplantation between monozygotic twins discordant for premature ovarian failure. NEJM. 2005;353:58–63.PubMedCrossRefGoogle Scholar
  59. 59.
    Silber SJ. Ovary cryopreservation and transplantation for fertility preservation. Mol Hum Reprod. 2012;18:59–67.PubMedCrossRefGoogle Scholar
  60. 60.
    Telfer EE, McLaughlin M, Ding C, Thong KJ. A two-step serum-free culture system supports development of human oocytes from primordial follicles in the presence of activin. Hum Reprod. 2008;23:1151–8.PubMedCrossRefGoogle Scholar
  61. 61.
    Wallace WH, Thomson AB, Saran F, Kelsey TW. Predicting age of ovarian failure after radiation to a field that includes the ovaries. Int J Radiat Oncol Biol Phys. 2005;62:738–44.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Marie-Madeleine Dolmans
    • 1
    • 2
  • Pascale Jadoul
    • 1
    • 2
  • Sébastien Gilliaux
    • 1
  • Christiani A. Amorim
    • 1
  • Valérie Luyckx
    • 1
    • 2
  • Jean Squifflet
    • 1
    • 2
  • Jacques Donnez
    • 1
    • 2
  • Anne Van Langendonckt
    • 1
  1. 1.Department of Gynecology, Institut de Recherche Expérimentale et Clinique (IREC)Université Catholique de LouvainBrusselsBelgium
  2. 2.Department of GynecologyCliniques Universitaires Saint LucBrusselsBelgium

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