Journal of Assisted Reproduction and Genetics

, Volume 30, Issue 2, pp 197–202 | Cite as

Mild ovarian stimulation for in vitro fertilization: one perspective from the USA




To provide a perspective regarding mild ovarian stimulation, taking into account particular issues relevant in the United States


Literature review and editorial commentary


Mild ovarian stimulation for IVF has some proven and some theoretical advantages over conventional stimulation, such as lower risk of ovarian hyperstimulation syndrome and lower cost per fresh IVF cycle. However, cumulative live birth rate, including transfers from fresh and frozen embryos, is likely to be lower with mild stimulation. The cost-effectiveness of mild stimulation IVF in the United States has not been established.


Mild ovarian stimulation is an appropriate option to consider for certain patient groups or based on patient preference. However, significant potential disadvantages limit its widespread acceptability for patients in the United States at this time.


Assisted reproductive technology In vitro fertilization Mild ovarian stimulation 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and GynecologyStanford University School of Medicine, Stanford Fertility and Reproductive Medicine CenterPalo AltoUSA

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