Journal of Assisted Reproduction and Genetics

, Volume 30, Issue 9, pp 1147–1156 | Cite as

Coenzyme Q10 and male infertility: a meta-analysis

  • Rafael LafuenteEmail author
  • Mireia González-Comadrán
  • Ivan Solà
  • Gemma López
  • Mario Brassesco
  • Ramón Carreras
  • Miguel A. Checa
Gonadal Physiology and Disease



To evaluate the effect of coenzyme Q10 treatments in male infertility, specifically in these parameters: live birth and pregnancy rates, CoQ10 seminal concentration, sperm concentration, and sperm motility.

Materials and methods

Systematic review and meta-analysis in male infertility patients with CoQ10 oral treatments. Three trials were included: 149 males in CoQ10 group and 147 males in placebo group.


None of the included trials provided any data regarding live births. The results of this meta-analysis show that supplementing infertile men with CoQ10 does not increase pregnancy rates. The analysis showed, among patients receiving CoQ10 treatment, a statistically significant increase in: CoQ10 seminal concentration (RR 49.55, 95 % CI 46.44 to 52.66, I2 = 17 %), sperm concentration (RR 5.33, 95 % CI 4.18 to 6.47, I2 = 58 %), and sperm motility (RR 4.50, 95 % CI 3.92 to 5.08, I2 = 0 %)


There is no evidence in the literature that CoQ10 increases either live birth or pregnancy rates, but there is a global improvement in sperm parameters. Adequately powered, robust trials of individual and combination antioxidant therapies are required to guide clinical practice.


Coenzyme Q10 Male infertility Randomized controlled trial Live birth 


Conflict of interest

The authors declare no conflict of interest.

Financial support



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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Rafael Lafuente
    • 1
    Email author
  • Mireia González-Comadrán
    • 3
  • Ivan Solà
    • 4
    • 5
  • Gemma López
    • 1
  • Mario Brassesco
    • 2
  • Ramón Carreras
    • 3
  • Miguel A. Checa
    • 3
  1. 1.Andrology LaboratoryCIRH. Clínica Corachan. ANACERBarcelonaSpain
  2. 2.Medical DepartmentCIRH. Clínica Corachan. ANACERBarcelonaSpain
  3. 3.Department of Obstetrics and GynecologyHospital del MarBarcelonaSpain
  4. 4.Iberoamerican Cochrane Centre, Institute of Biomedical ResearchIIB Sant PauBarcelonaSpain
  5. 5.CIBER de Epidemiología y Salud Pública (CIBERESP)BarcelonaSpain

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