Legal termination of a pregnancy resulting from transplanted cryopreserved ovarian tissue due to cancer recurrence

  • Emil Hagen Ernst
  • Birgitte Vrou Offersen
  • Claus Yding Andersen
  • Erik Ernst
Fertility Preservation



To report on a woman who conceived naturally and had a normal intrauterine pregnancy following transplantation of frozen/thawed ovarian tissue but decided to have an early abortion due to recurrence of breast cancer.


The patient was diagnosed breast cancer and received antineoplastic treatment that forced her into premature ovarian insufficiency and infertility. Ovarian tissue cryopreserved prior to chemotherapy was transplanted following cancer treatment restoring fertility and regular menstrual cycles.


The patient conceived 6 month after transplantation. However, she experienced recurrence of breast cancer and decided on legal termination of the pregnancy in the first trimester.


The obtained pregnancy only 6 month following transplantation underlines the ability of the procedure. The recurrence occurred near the original site of the tumor and was most unlikely related to the transplantation. The activity of the transplanted tissue is likely to be destroyed by the renewed antineoplastic treatment she will receive. However, she still has the majority of one ovary cryostored and may later want to undergo additional transplantation to regain fertility or to have menstrual cycles back.


Transplantation Fertility preservation Cancer Ovarian cryopreservation Premature ovarian insufficiency 



The financial support from the foundations of Civil Engineer Frode V. Nyegaard & wife, The Health Faculty at Aarhus University, the Danish Cancer Society (DP05112/ R2-A41-09-S2), The Danish Medical Research Council (271-07-0452; 09-072265), the Novo Nordic Foundation, Sophus Carl Emil Friis and wife Olga Doris Friis’ foundation, and the University Hospital of Copenhagen, is gratefully acknowledged.

Conflict of interest

None declared


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Emil Hagen Ernst
    • 1
  • Birgitte Vrou Offersen
    • 2
  • Claus Yding Andersen
    • 3
  • Erik Ernst
    • 4
  1. 1.Institute for Biomedicine – Section WestAarhus UniversityAarhus CDenmark
  2. 2.Department of OncologyAarhus University HospitalAarhusDenmark
  3. 3.Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital, Faculty of Health SciencesCopenhagen UniversityCopenhagenDenmark
  4. 4.Department of Gynaecology and ObstetricsAarhus University HospitalAarhusDenmark

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