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Evaluation of ovarian and testicular tissue cryopreservation in children undergoing gonadotoxic therapies

  • Samir N. Babayev
  • Erol Arslan
  • Stanley Kogan
  • Fred Moy
  • Kutluk Oktay
Fertility Preservation

Abstract

Objective

Ovarian and testicular tissue cryopreservation are the only fertility preservation options for sexually immature individuals. Because of their experimental nature, it is important to determine safety and possible bundling with other medicallyindicated procedures.

Study design

Prospective observational.

Results

Cryopreservation indications included cancer in 75 % of females and 50 % of males, while non-cancer indications included various hematological conditions. Similar numbers of females (12/28) and males (3/9) underwent prior chemotherapy. Females underwent laparoscopic (27/28) or robotic (1/28) approaches while incisional biopsy was used in males. Bundling of ovarian and testicular harvesting with other medicallyindicated procedures was performed in 42 % and 22 %, respectively. The operative time inclusive of bundled procedures was similar (1.6 ± 0.1 vs. 0.9 ± 0.3 h) but the discharge time was significantly longer for females than males (10.4 ± 0.6 vs. 4.6 ± 0.6 h, p < 0.05) due to frequent bundling of medically-indicated procedures in females. All procedures were successfully completed without complications or significant blood loss.

Conclusions

Pediatric gonadal tissue cryopreservation can be combined with other medically-indicated procedures to minimize the potential inconvenience, additional anesthetic risks, and costs.

Keywords

Hematology/oncology Children Cryopreservation Fertility preservation 

Notes

Acknowledgments

This study was supported by the National Institute of Child Health and Development as well as National Cancer Institute, National Institute of Health (HD 053112 and R21HD061259) to KO.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Samir N. Babayev
    • 1
  • Erol Arslan
    • 1
    • 2
  • Stanley Kogan
    • 5
  • Fred Moy
    • 1
    • 2
    • 3
    • 6
  • Kutluk Oktay
    • 1
    • 2
    • 3
    • 4
    • 7
    • 8
  1. 1.Department of Obstetrics and GynecologyNew York Medical CollegeValhallaUSA
  2. 2.Department of Cell Biology and AnatomyNew York Medical CollegeValhallaUSA
  3. 3.Department of PathologyNew York Medical CollegeValhallaUSA
  4. 4.Department of MedicineNew York Medical CollegeValhallaUSA
  5. 5.Department of UrologyNew York Medical CollegeValhallaUSA
  6. 6.Biometric, Data Management and PK/PD Unit, Graduate School of Basic Medical Sciences, Department of PathologyNew York Medical CollegeValhallaUSA
  7. 7.Division of Reproductive Medicine & Infertility, and Institute for Fertility PreservationNew York Medical CollegeRye and ValhallaUSA
  8. 8.Laboratory of Molecular Reproduction and Fertility PreservationNew York Medical CollegeValhallaUSA

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