Journal of Assisted Reproduction and Genetics

, Volume 29, Issue 6, pp 495–502

Ovarian tissue cryopreservation for fertility preservation in cancer patients: Successful establishment and feasibility of a multidisciplinary collaboration

  • Clarisa R. Gracia
  • Jeff Chang
  • Laxmi Kondapalli
  • Maureen Prewitt
  • Claire A. Carlson
  • Peter Mattei
  • Shanaye Jeffers
  • Jill P. Ginsberg
Fertility Preservation

DOI: 10.1007/s10815-012-9753-7

Cite this article as:
Gracia, C.R., Chang, J., Kondapalli, L. et al. J Assist Reprod Genet (2012) 29: 495. doi:10.1007/s10815-012-9753-7

Abstract

Background

As advancements in cancer therapies have led to dramatic improvements in long term survival, there has been increasing interest in methods to expand fertility preservation options for cancer patients.

Methods

An experimental protocol for ovarian tissue cryopreservation was developed at the University of Pennsylvania for patients requiring gonadotoxic therapies. The protocol for adults was implemented at the Hospital of the University of Pennsylvania and for children at the Children’s Hospital of Philadelphia in collaboration with the Oncofertility Consortium and the National Physicians Cooperative (NPC).

Results

A total of twenty-one patients (age range: 8–36 years) have cryopreserved ovarian tissue as part of this study. While patients had a variety of diagnoses and treatment exposures, 10/21 (48 %) patients suffered from hematologic disorders and 43 % were anticipating stem cell transplantation. No patients have requested that the tissue be used for clinical purposes.

Conclusions

Ovarian tissue cryopreservation protocols can be implemented at pediatric and adult institutions through multi-disciplinary collaboration. While more research is needed to determine the safety and efficacy of ovarian tissue cryopreservation, this procedure provides hope for preserving the ability to have biological offspring to patients facing gonadotoxic therapies for a variety of medical conditions.

Keywords

Ovarian tissue Cryopreservation Fertility preservation Cancer Oncofertility 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Clarisa R. Gracia
    • 1
    • 2
  • Jeff Chang
    • 3
  • Laxmi Kondapalli
    • 4
  • Maureen Prewitt
    • 1
    • 6
  • Claire A. Carlson
    • 5
  • Peter Mattei
    • 8
  • Shanaye Jeffers
    • 7
  • Jill P. Ginsberg
    • 5
  1. 1.Departments of Obstetrics/GynecologyUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Division of Reproductive Endocrinology and InfertilityUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Division of Reproductive EndocrinologyUniversity of California at San DiegoSan DiegoUSA
  4. 4.Division of Reproductive EndocrinologyUniversity of ColoradoBoulderUSA
  5. 5.Division of Pediatric OncologyChildren’s Hospital of PhiladelphiaPhiladelphiaUSA
  6. 6.Center for Research in Reproduction and Women’s HealthUniversity of PennsylvaniaPhiladelphiaUSA
  7. 7.Haverford CollegeHaverfordUSA
  8. 8.Department of Pediatric SurgeryChildren’s Hospital of PhiladelphiaPhiladelphiaUSA

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