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Journal of Assisted Reproduction and Genetics

, Volume 29, Issue 3, pp 249–253 | Cite as

Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS

  • Juan C. CastilloEmail author
  • Juan Garcia-Velasco
  • Peter Humaidan
ASSISTED REPRODUCTION TECHNOLOGIES

Abstract

Purpose

This study aimed to explore the incidence of empty follicle syndrome (EFS) in oocyte donors who had final oocyte maturation triggered with GnRHa and to compare the incidence of EFS in this group of patients with IVF patients who had final oocyte maturation with hCG.

Methods

Data including 2034 oocyte donation cycles and 1433 IVF cycles performed between years 2009 and 2010 was retrospectively analyzed to identify cases of EFS in each group.

Results

The incidence of EFS in the two groups did not differ significantly, 3.5% versus 3.1%, (n.s.).

Conclusions

This large retrospective analysis indicates that the incidence of EFS is not increased after GnRHa triggering as compared to hCG triggering.

Keywords

GnRH agonist GnRH antagonist GnRHa triggering hCG Empty follicle syndrome 

Notes

Acknowledgements

The authors would like to acknowledge Dr Claudio Bonomini for his invaluable help in data search.

The authors disclose any potential conflict of interest.

References

  1. 1.
    Humaidan P, Kol S, Papanikolaou E, The Copenhagen GnRH Agonist Triggering Workshop Group. GnRH agonist for triggering of final oocyte maturation: time for a change of practice? Hum Reprod Update. 2011;17:510–4.PubMedCrossRefGoogle Scholar
  2. 2.
    Honnma H, Hashiba Y, Asada Y, Endo T. Failure of triggering oocyte maturation with a GnRH agonist in polycystic ovary syndrome: two case reports. Eur J Obstet Gynecol Reprod Biol In Press. doi: 10.1016/j.ejogrb.2011.03.002.
  3. 3.
    Griesinger G, Schultz L, Bauer T, Broessner A, Frambach T, Kissler S. Ovarian hyperstimulation syndrome prevention by gonadotropin-releasing hormone agonist triggering of final oocyte maturation in a gonadotropin-releasing hormone antagonist protocol in combination with a “freeze-all” strategy: a prospective multicentric study. Fertil Steril. 2011;95:2029–33.PubMedCrossRefGoogle Scholar
  4. 4.
    Ben-Shlomo I, Schiff E, Levran D, Ben-Rafael Z. Failure of oocyte retrieval during invitro fertilization: a sporadic event rather than a syndrome. Fertil Steril. 1991;55:324–7.PubMedGoogle Scholar
  5. 5.
    Awonuga A, Govindbhai J, Zierke S, Schnauffer K. Continuing the debate on empty follicle syndrome: can it be associated with normal bioavailability of b-human chorionic gonadotrophin on the day of oocyte recovery? Hum Reprod. 1998;13:1281–4.PubMedCrossRefGoogle Scholar
  6. 6.
    Zreik TG, Garcia-Velasco JA, Vergara TM, Arici A, Olive D, Jones EE. Empty follicle syndrome: evidence for recurrence. Hum Reprod. 2000;15:999–1002.PubMedCrossRefGoogle Scholar
  7. 7.
    Zegers-Hochschild F, Fernandez E, Machenna A, Fabres C, Alteiri E, Lopez T. The empty follicle syndrome: a pharmaceutical industry syndrome. Hum Reprod. 1995;10:2262–5.PubMedGoogle Scholar
  8. 8.
    Ndukwe G, Thornton S, Fishel S, Dowell K, Aloum M, Green S. ‘Curing’ empty follicle syndrome. Hum Reprod. 1997;12:21–3.PubMedCrossRefGoogle Scholar
  9. 9.
    Ubaldi F, Nagy Z, Janssenwillen C, Smitz J, Van Steirteghem A, Devroey P. Ovulation by repeated human chorionic gonadotrophin in ‘empty follicle syndrome’ yields a twin clinical pregnancy. Hum Reprod. 1997;12:454–6.PubMedCrossRefGoogle Scholar
  10. 10.
    Quintans CJ, Donaldson MJ, Blanco LA, Pasqualini RS. Empty follicle syndrome due to human errors: its occurrence in an in-vitro fertilization programme. Hum Reprod. 1998;13:2703–5.PubMedGoogle Scholar
  11. 11.
    Gonen Y, Balakier H, Powell W, Casper RF. Use of gonadotropin-releasing hormone agonist to trigger follicular maturation for in vitro fertilization. J Clin Endocrinol Metab. 1990;71:918–22.PubMedCrossRefGoogle Scholar
  12. 12.
    Itskovitz J, Boldes R, Levron J, Erlik Y, Kahana L, Brandes JM. Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonist. Fertil Steril. 1991;56:213–20.PubMedGoogle Scholar
  13. 13.
    Hoff JD, Quigley ME, Yen SS. Hormonal dynamics at midcycle: a reevaluation. J Clin Endocrinol Metab. 1983;57:792–6.PubMedCrossRefGoogle Scholar
  14. 14.
    Damewood MD, Shen W, Zacur HA, Schlaff WD, Rock JA, Wallach EE. Disappearance of exogenously administered human chorionic gonadotropin. Fertil Steril. 1989;52:398–400.PubMedGoogle Scholar
  15. 15.
    Weissman A, Lurie S, Zalel Y, Goldchmit R, Shoham Z. Human chorionic gonadotropin: pharmacokinetics of subcutaneous administration. Gynecol Endocrinol. 1996;10:273–6.PubMedCrossRefGoogle Scholar
  16. 16.
    Stevenson TL, Lashen H. Empty follicle syndrome: the reality of a controversial syndrome, a systematic review. Fertil Steril. 2008;90:691–8.PubMedCrossRefGoogle Scholar
  17. 17.
    Parneix I, Emperaire JC, Ruffie A, Parneix P. Comparison of different protocols of ovulation induction, by GnRH agonists and chorionic gonadotropin. Gynecol Obstet Fertil. 2001;29:100–5.PubMedCrossRefGoogle Scholar
  18. 18.
    Díaz I, Guillén A, Pacheco A, Requena A, Garcia-Velasco JA. Endocrine modifications associated with final oocyte maturation with gonadotropin-releasing hormone agonists vs. human chorionic gonadotropin in women undergoing intrauterine insemination. J Reprod Med. 2008;53:33–9.PubMedGoogle Scholar
  19. 19.
    Fauser BC, de Jong D, Olivennes F, Wramsby H, Tay C, Itskovitz-Eldor J, van Hooren HG. Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab. 2002;87:709–15.PubMedCrossRefGoogle Scholar
  20. 20.
    Engmann L, Siano L, Schmidt D, Nulsen J, Maier D, Benadiva C. GnRH agonist to induce oocyte maturation during IVF in patients at high risk of OHSS. Reprod Biomed Online. 2006;13:639–44.PubMedCrossRefGoogle Scholar
  21. 21.
    Bodri D, Guillén JJ, Trullenque M, Schwenn K, Esteve C, Coll O. Early ovarian hyperstimulation syndrome is completely prevented by gonadotropin releasing-hormone agonist triggering in high-risk oocyte donor cycles: a prospective, luteal-phase follow-up study. Fertil Steril. 2010;93:2418–20.PubMedCrossRefGoogle Scholar
  22. 22.
    Yariz KO, Walsh T, Uzak A, Spiliopoulos M, Duman D, Onalan G, King MC, Tekin M. Inherited mutation of the luteinizing hormone/choriogonadotropin receptor (LHCGR) in empty follicle syndrome. Fertil Steril. 2011 (in press).Google Scholar
  23. 23.
    Khalaf Y, Braude P. ‘Curing’ empty follicle syndrome. Hum Reprod. 1997;12:1601.PubMedGoogle Scholar
  24. 24.
    Tsuiki A, Rose BI, Hung TT. Steroid profiles of follicular fluids from a patient with the empty follicle syndrome. Fertil Steril. 1988;49:104–7.PubMedGoogle Scholar
  25. 25.
    Beranova M, Oliveira LM, Bédécarrats GY, Schipani E, Vallejo M, Ammini AC, Quintos JB, Hall JE, Martin KA, Hayes FJ, Pitteloud N, Kaiser UB, Crowley Jr WF, Seminara SB. Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2001;86:1580–8.PubMedCrossRefGoogle Scholar
  26. 26.
    Perez Mayorga M, Gromoll J, Behre HM, Gassner C, Nieschlag E, Simoni M. Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype. J Clin Endocrinol Metab. 2000;85:3365–9.PubMedCrossRefGoogle Scholar
  27. 27.
    Piersma D, Verhoef-Post M, Berns EM, Themmen AP. LH receptor gene mutations and polymorphisms: an overview. Mol Cell Endocrinol. 2007;260–262:282–6.PubMedCrossRefGoogle Scholar
  28. 28.
    Alviggi C, Clarizia R, Pettersson K, Mollo A, Humaidan P, Strina I, Coppola M, Ranieri A, D’Uva M, De Placido G. Suboptimal response to GnRHa long protocol is associated with a common LH polymorphism. Reprod Biomed Online. 2009;18:9–14.PubMedCrossRefGoogle Scholar
  29. 29.
    Pettersson KS, Söderholm JR. Individual differences in lutropin immunoreactivity revealed by monoclonal antibodies. Clin Chem. 1991;37:333–40.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Juan C. Castillo
    • 1
    Email author
  • Juan Garcia-Velasco
    • 2
  • Peter Humaidan
    • 3
  1. 1.FIV ValenciaValenciaSpain
  2. 2.IVI MadridMadridSpain
  3. 3.The Fertility Clinic, Department DOdense University HospitalOdenseDenmark

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