Journal of Assisted Reproduction and Genetics

, Volume 28, Issue 10, pp 901–910 | Cite as

The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis

ASSISTED REPRODUCTION TECHNOLOGIES

Abstract

Objective

To evaluate the relationship between different hCG priming-to-oocyte retrieval intervals and assisted reproductive technology (ART) outcome.

Methods

We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index, Chinese biomedicine (CBM) literature database, and Chinese Journal Full-text Database for randomized controlled trials (RCTs) published up to November 2010. Data was extracted from the studies by two independent reviewers. Statistical analysis was performed with Cochrane Collaboration’s Review Manager (RevMan) 5.0.2. From extracted data, Risk Ratio (RR) with 95% confidence interval (CI) was calculated.

Results

5 RCTs totaling 895 participants were included. Oocyte maturation rate was higher in the long interval group compared with short interval group (RR, 0.67; 95% CI, 0.62–0.73). There were no significant difference between the two groups with regard to fertilization rate (RR, 0.99; 95% CI, 0.94–1.04), implantation rate (RR, 0.91; 95% CI, 0.40–2.04), and pregnancy rate (RR, 0.79; 95% CI, 0.58–1.08).

Conclusion

The percentage of mature (MII) oocytes can be increased by prolonging the interval between hCG priming and oocyte retrieval. The prolonged interval could not increase the fertilization rate, implantation rate, and pregnancy rate. Although there was evidence to confirm the results, they still need to be confirmed by large-sample, multicenter, randomized controlled trials. The time interval dependent mechanisms responsible for ART performance need to be elucidated.

Keywords

Human chorionic gonadotropin Oocyte retrieval Time interval Infertility Assisted reproductive technology Meta-analysis 

Abbreviations

ART

Assisted reproductive technology

ATP

Adenosine triphosphate

CC

Clomiphene citrate

COH

Controlled ovarian hyperstimulation

ET

Embryo transfer

FSH

Follicle-stimulating hormone

GnRH-a

Gonadotropic hormone releasing hormone analogue

hCG

Human chorionic gonadotropin

hMG

Human menopausal gonadotropin

ICSI

Intracytoplasmic sperm injection

IGF

Insulin-like growth factor

IL

Interleukin

IM

Intramuscular injection

IUI

Intrauterine insemination

IVF

In vitro fertilization

IVM

In vitro maturation

LH

Luteinizing hormone

LI

Long interval

MII

Metaphase II

NA

Not available

RCT

Randomized controlled trial

RevMan

Review Manager

RR

Risk ratio

SI

Short interval

TUS

Transvaginal ultrasound

VEGF

Vascular endothelial growth factor

2PN

Two-pronuclear

95% CI

95% confidence interval

Notes

Acknowledgments

The authors would like to thank Jin-Hui Tian, Bin Ma, Lei Jiang, Wen-Qin Jia, Kang Yi, and Lun Li (Evidence-Based Medicine Center of Lanzhou University, Lanzhou, China) for advice on conducting the meta-analysis and writing the article.

Conflicts of interest statement

The authors declared no conflicts of interest related to this study.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.The Reproductive Medicine Centerthe First Hospital of Lanzhou UniversityLanzhouChina
  2. 2.The Evidence-Based Medicine Center of Lanzhou UniversityLanzhouChina

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