The time interval between hCG priming and oocyte retrieval in ART program: a meta-analysis
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To evaluate the relationship between different hCG priming-to-oocyte retrieval intervals and assisted reproductive technology (ART) outcome.
We systematically searched PubMed, EMBASE, the Cochrane Library, Science Citation Index, Chinese biomedicine (CBM) literature database, and Chinese Journal Full-text Database for randomized controlled trials (RCTs) published up to November 2010. Data was extracted from the studies by two independent reviewers. Statistical analysis was performed with Cochrane Collaboration’s Review Manager (RevMan) 5.0.2. From extracted data, Risk Ratio (RR) with 95% confidence interval (CI) was calculated.
5 RCTs totaling 895 participants were included. Oocyte maturation rate was higher in the long interval group compared with short interval group (RR, 0.67; 95% CI, 0.62–0.73). There were no significant difference between the two groups with regard to fertilization rate (RR, 0.99; 95% CI, 0.94–1.04), implantation rate (RR, 0.91; 95% CI, 0.40–2.04), and pregnancy rate (RR, 0.79; 95% CI, 0.58–1.08).
The percentage of mature (MII) oocytes can be increased by prolonging the interval between hCG priming and oocyte retrieval. The prolonged interval could not increase the fertilization rate, implantation rate, and pregnancy rate. Although there was evidence to confirm the results, they still need to be confirmed by large-sample, multicenter, randomized controlled trials. The time interval dependent mechanisms responsible for ART performance need to be elucidated.
KeywordsHuman chorionic gonadotropin Oocyte retrieval Time interval Infertility Assisted reproductive technology Meta-analysis
Assisted reproductive technology
Controlled ovarian hyperstimulation
Gonadotropic hormone releasing hormone analogue
Human chorionic gonadotropin
Human menopausal gonadotropin
Intracytoplasmic sperm injection
Insulin-like growth factor
In vitro fertilization
In vitro maturation
Randomized controlled trial
Vascular endothelial growth factor
- 95% CI
95% confidence interval
The authors would like to thank Jin-Hui Tian, Bin Ma, Lei Jiang, Wen-Qin Jia, Kang Yi, and Lun Li (Evidence-Based Medicine Center of Lanzhou University, Lanzhou, China) for advice on conducting the meta-analysis and writing the article.
Conflicts of interest statement
The authors declared no conflicts of interest related to this study.
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