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Journal of Assisted Reproduction and Genetics

, Volume 28, Issue 9, pp 773–783 | Cite as

The contribution of mitochondrial function to reproductive aging

  • Yaakov Bentov
  • Tetyana Yavorska
  • Navid Esfandiari
  • Andrea Jurisicova
  • Robert F. CasperEmail author
Review

Abstract

Purpose

The number of women attempting to conceive between the ages of 36 and 44 has increased significantly in the last decade. While it is well established that women’s reproductive success dramatically declines with age, the underlying physiological changes responsible for this phenomenon are not well understood. With assisted reproductive technologies, it is clear that oocyte quality is a likely cause since women over 40 undergoing in vitro fertilization (IVF) with oocytes donated by younger women have success rates comparable to young patients. Apart from oocyte donation, there is no known intervention to improve the pregnancy outcome of older patients. The aim of this paper was the review the relevant data on the potential role of mitochondria in reproductive aging.

Method

Review of current literature on the subject.

Results

We present the current evidence that associate mitochondrial dysfunction with age related decrease in female reproductive outcome.

Conclusions

The aging process is complex, driven by a multitude of factors thought to modulate cellular and organism life span. Although the factors responsible for diminished oocyte quality remain to be elucidated, the present review focuses on the potential role of impaired mitochondrial function.

Keywords

Reproductive aging Oocyte Embryo Aneuploidy Mitochondria Mitochondrial DNA 

Notes

Disclosure

YB, TY, AJ, NE and RFC have nothing to disclose.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Yaakov Bentov
    • 1
    • 2
    • 5
  • Tetyana Yavorska
    • 3
    • 6
  • Navid Esfandiari
    • 1
    • 2
  • Andrea Jurisicova
    • 2
    • 3
    • 6
  • Robert F. Casper
    • 1
    • 2
    • 4
    • 5
    Email author
  1. 1.Toronto Centre for Advanced Reproductive TechnologyUniversity of TorontoTorontoCanada
  2. 2.Division of Reproductive Sciences, Department of Obstetrics and GynecologyUniversity of TorontoTorontoCanada
  3. 3.Department of PhysiologyUniversity of TorontoTorontoCanada
  4. 4.Department of Obstetrics PhysiologyUniversity of TorontoTorontoCanada
  5. 5.Samuel Lunenfeld Research Institute, Mount Sinai HospitalUniversity of TorontoTorontoCanada
  6. 6.Samuel Lunenfeld Research Institute, Mount Sinai HospitalUniversity of TorontoTorontoCanada

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