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Journal of Assisted Reproduction and Genetics

, Volume 28, Issue 2, pp 145–149 | Cite as

Cytogenetic abnormalities in 1162 couples with recurrent miscarriages in Southern region of India: report and review

  • Usha R. Dutta
  • P. Rajitha
  • Vijaya Kumar Pidugu
  • Ashwin B. Dalal
Genetics

Abstract

Purpose

The purpose of the present study was to investigate the contribution of chromosomal anomalies and the frequency of a particular type of aberration in couples with recurrent miscarriages.

Methods

A total of 1,162 couples with recurrent miscarriages were analyzed using G-banding and Fluorescence in situ hybridization where ever necessary.

Results

Chromosomal anomalies were detected in 78 cases. This study describes majority of the cases with balanced reciprocal translocations. Among the abnormal karyotypes we also report for the first time three unique translocations involving (3;14), (18;22) and (X;22) chromosomes which were confirmed by molecular cytogenetic methods.

Conclusions

The review of literature and the overall incidence of the abnormalities suggest that chromosomal analysis in couples with recurrent miscarriages should be taken up by all the practioners at all levels. This not only helps to check the cytological abnormalities but also helps to correlate the recurrent abnormalities in a given population. Thus establishing and correlating the environmental and genetic condition of that particular phenotype and genotype.

Keywords

Breakpoints Chromosomal abnormalities Recurrent miscarriages Translocations 

Notes

Acknowledgements

This study was supported by a core grant to the Centre for DNA Fingerprinting and Diagnostics, from the Department of Biotechnology, Government of India.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Usha R. Dutta
    • 1
  • P. Rajitha
    • 1
  • Vijaya Kumar Pidugu
    • 1
  • Ashwin B. Dalal
    • 1
  1. 1.Diagnostics DivisionCenter for DNA Fingerprinting and DiagnosticsHyderabadIndia

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