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Journal of Assisted Reproduction and Genetics

, Volume 27, Issue 9–10, pp 539–544 | Cite as

Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles

  • Julia Keltz
  • Athena Zapantis
  • Sangita K. Jindal
  • Harry J. Lieman
  • Nanette Santoro
  • Alex J. Polotsky
Assisted Reproduction

Abstract

Purpose

To evaluate if elevated male body mass influences success after assisted reproductive technologies

Methods

Retrospective study of 290 cycles.

Results

Male body mass index greater than 25.0 kg/m2 was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07–0.69] vs. 0.75 [0.38–1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass.

Conclusion

In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.

Keywords

Male obesity In vitro fertilization IVF/ICSI outcome Assisted reproduction 

Notes

Acknowledgments

Supported in part by K24 HD 41978 (NS)

References

  1. 1.
    Stewart ST, Cutler DM, Rosen AB. Forecasting the effects of obesity and smoking on U.S. life expectancy. N Engl J Med. 2009;361:2252–60.CrossRefPubMedGoogle Scholar
  2. 2.
    Olshansky SJ, Passaro DJ, Hershow RC, Layden J, Carnes BA, Brody J, et al. A potential decline in life expectancy in the United States in the 21st century. N Engl J Med. 2005;352:1138–45.CrossRefPubMedGoogle Scholar
  3. 3.
    Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM. Prevalence of overweight and obesity in the United States, 1999–2004. JAMA. 2006;295:1549–55.CrossRefPubMedGoogle Scholar
  4. 4.
    Wang Y, Beydoun MA. The obesity epidemic in the United States—gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev. 2007;29:6–28.CrossRefPubMedGoogle Scholar
  5. 5.
    Obesity and reproduction: an educational bulletin. Fertil Steril 2008;90(5 Suppl):S21–S9.Google Scholar
  6. 6.
    The ESHRE Capri Workshop Group. Nutrition and reproduction in women. Hum Reprod Update. 2006;12:193–207.CrossRefGoogle Scholar
  7. 7.
    Polotsky AJ, Hailpern SM, Skurnick JH, Lo JC, Sternfeld B, Santoro N. Association of adolescent obesity and lifetime nulliparity-The Study of Women's Health Across the Nation (SWAN). Fertil Steril 2009.Google Scholar
  8. 8.
    Ramlau-Hansen CH, Thulstrup AM, Nohr EA, Bonde JP, Sorensen TI, Olsen J. Subfecundity in overweight and obese couples. Hum Reprod. 2007;22:1634–7.CrossRefPubMedGoogle Scholar
  9. 9.
    Speakman JR, Djafarian K, Stewart J, Jackson DM. Assortative mating for obesity. Am J Clin Nutr. 2007;86:316–23.PubMedGoogle Scholar
  10. 10.
    Silventoinen K, Kaprio J, Lahelma E, Viken RJ, Rose RJ. Assortative mating by body height and BMI: Finnish twins and their spouses. Am J Hum Biol. 2003;15:620–7.CrossRefPubMedGoogle Scholar
  11. 11.
    Sallmen M, Sandler DP, Hoppin JA, Blair A, Baird DD. Reduced fertility among overweight and obese men. Epidemiology. 2006;17:520–3.CrossRefPubMedGoogle Scholar
  12. 12.
    Nguyen RH, Wilcox AJ, Skjaerven R, Baird DD. Men's body mass index and infertility. Hum Reprod. 2007;22:2488–93.CrossRefPubMedGoogle Scholar
  13. 13.
    Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meikle AW. Male obesity and alteration in sperm parameters. Fertil Steril. 2008;90:2222–5.CrossRefPubMedGoogle Scholar
  14. 14.
    Jensen TK, Andersson AM, Jorgensen N, Andersen AG, Carlsen E, Petersen JH, et al. Body mass index in relation to semen quality and reproductive hormones among 1, 558 Danish men. Fertil Steril. 2004;82:863–70.CrossRefPubMedGoogle Scholar
  15. 15.
    Hofny ER, Ali ME, Abdel-Hafez HZ, El-Dien Kamal E, Mohamed EE, Abd El-Azeem HG et al. Semen parameters and hormonal profile in obese fertile and infertile males. Fertil Steril 2009.Google Scholar
  16. 16.
    Kort HI, Massey JB, Elsner CW, Mitchell-Leef D, Shapiro DB, Witt MA, et al. Impact of body mass index values on sperm quantity and quality. J Androl. 2006;27:450–2.CrossRefPubMedGoogle Scholar
  17. 17.
    Magnusdottir EV, Thorsteinsson T, Thorsteinsdottir S, Heimisdottir M, Olafsdottir K. Persistent organochlorines, sedentary occupation, obesity and human male subfertility. Hum Reprod. 2005;20:208–15.CrossRefPubMedGoogle Scholar
  18. 18.
    Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril 2009.Google Scholar
  19. 19.
    Vermeulen A, Kaufman JM, Deslypere JP, Thomas G. Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab. 1993;76:1140–6.CrossRefPubMedGoogle Scholar
  20. 20.
    Obesity: Preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i–xii, 1–253.Google Scholar
  21. 21.
    Polotsky AJ, Daif JL, Jindal S, Lieman HJ, Santoro N, Pal L. Serum progesterone on the day of human chorionic gonadotropin administration predicts clinical pregnancy of sibling frozen embryos. Fertil Steril. 2009;92:1880–5.CrossRefPubMedGoogle Scholar
  22. 22.
    Devroey P, Van Steirteghem A. A review of ten years experience of ICSI. Hum Reprod Update. 2004;10:19–28.CrossRefPubMedGoogle Scholar
  23. 23.
    Kurth T, Walker AM, Glynn RJ, Chan KA, Gaziano JM, Berger K, et al. Results of multivariable logistic regression, propensity matching, propensity adjustment, and propensity-based weighting under conditions of nonuniform effect. Am J Epidemiol. 2006;163:262–70.CrossRefPubMedGoogle Scholar
  24. 24.
    Rogers J, Mitchell Jr GW. The relation of obesity to menstrual disturbances. N Engl J Med. 1952;247:53–5.CrossRefPubMedGoogle Scholar
  25. 25.
    Grodstein F, Goldman MB, Cramer DW. Body mass index and ovulatory infertility. Epidemiology. 1994;5:247–50.CrossRefPubMedGoogle Scholar
  26. 26.
    Gesink Law DC, Maclehose RF, Longnecker MP. Obesity and time to pregnancy. Hum Reprod. 2007;22:414–20.CrossRefPubMedGoogle Scholar
  27. 27.
    Jensen TK, Scheike T, Keiding N, Schaumburg I, Grandjean P. Fecundability in relation to body mass and menstrual cycle patterns. Epidemiology. 1999;10:422–8.CrossRefPubMedGoogle Scholar
  28. 28.
    Bolumar F, Olsen J, Rebagliato M, Saez-Lloret I, Bisanti L. Body mass index and delayed conception: a European Multicenter Study on Infertility and Subfecundity. Am J Epidemiol. 2000;151:1072–9.PubMedGoogle Scholar
  29. 29.
    Maheshwari A, Stofberg L, Bhattacharya S. Effect of overweight and obesity on assisted reproductive technology—a systematic review. Hum Reprod Update. 2007;13:433–44.CrossRefPubMedGoogle Scholar
  30. 30.
    Sneed ML, Uhler ML, Grotjan HE, Rapisarda JJ, Lederer KJ, Beltsos AN. Body mass index: impact on IVF success appears age-related. Hum Reprod. 2008;23:1835–9.CrossRefPubMedGoogle Scholar
  31. 31.
    Jain A, Polotsky AJ, Rochester D, Berga SL, Loucks T, Zeitlian G, et al. Pulsatile luteinizing hormone amplitude and progesterone metabolite excretion are reduced in obese women. J Clin Endocrinol Metab. 2007;92:2468–73.CrossRefPubMedGoogle Scholar
  32. 32.
    Schneider G, Kirschner MA, Berkowitz R, Ertel NH. Increased estrogen production in obese men. J Clin Endocrinol Metab. 1979;48:633–8.CrossRefPubMedGoogle Scholar
  33. 33.
    Giagulli VA, Kaufman JM, Vermeulen A. Pathogenesis of the decreased androgen levels in obese men. J Clin Endocrinol Metab. 1994;79:997–1000.CrossRefPubMedGoogle Scholar
  34. 34.
    Clark AM, Thornley B, Tomlinson L, Galletley C, Norman RJ. Weight loss in obese infertile women results in improvement in reproductive outcome for all forms of fertility treatment. Hum Reprod. 1998;13:1502–5.CrossRefPubMedGoogle Scholar
  35. 35.
    Marceau P, Kaufman D, Biron S, Hould FS, Lebel S, Marceau S, et al. Outcome of pregnancies after biliopancreatic diversion. Obes Surg. 2004;14:318–24.CrossRefPubMedGoogle Scholar
  36. 36.
    Rochester D, Jain A, Polotsky AJ, Polotsky H, Gibbs K, Isaac B, et al. Partial recovery of luteal function after bariatric surgery in obese women. Fertil Steril. 2009;92:1410–5.CrossRefPubMedGoogle Scholar
  37. 37.
    Krishnamoorthy U, Schram CM, Hill SR. Maternal obesity in pregnancy: Is it time for meaningful research to inform preventive and management strategies? Bjog. 2006;113:1134–40.PubMedGoogle Scholar
  38. 38.
    Smajdor A. Should IVF guidelines be relaxed in the UK? Expert Rev Obstet & Gynecol. 2009;4:501–8.Google Scholar
  39. 39.
    di Frega AS, Dale B, Di Matteo L, Wilding M. Secondary male factor infertility after Roux-en-Y gastric bypass for morbid obesity: case report. Hum Reprod. 2005;20:997–8.CrossRefPubMedGoogle Scholar
  40. 40.
    Globerman H, Shen-Orr Z, Karnieli E, Aloni Y, Charuzi I. Inhibin B in men with severe obesity and after weight reduction following gastroplasty. Endocr Res. 2005;31:17–26.CrossRefPubMedGoogle Scholar
  41. 41.
    Bastounis EA, Karayiannakis AJ, Syrigos K, Zbar A, Makri GG, Alexiou D. Sex hormone changes in morbidly obese patients after vertical banded gastroplasty. Eur Surg Res. 1998;30:43–7.CrossRefPubMedGoogle Scholar
  42. 42.
    Betz NE, Mintz L, Speakmon G. Gender differences in the accuracy of self-reported weight. Sex Roles. 1994;30:543–52.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Julia Keltz
    • 1
  • Athena Zapantis
    • 1
    • 2
  • Sangita K. Jindal
    • 1
    • 2
  • Harry J. Lieman
    • 1
    • 2
  • Nanette Santoro
    • 1
    • 2
    • 3
  • Alex J. Polotsky
    • 1
    • 2
  1. 1.Department of Obstetrics and Gynecology and Women’s HealthAlbert Einstein College of MedicineBronxUSA
  2. 2.Montefiore’s Institute for Reproductive Medicine and HealthAlbert Einstein College of Medicine and Montefiore Medical CenterBronxUSA
  3. 3.Department of Obstetrics and GynecologyUniversity of ColoradoDenverUSA

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