Overweight Men: clinical pregnancy after ART is decreased in IVF but not in ICSI cycles
To evaluate if elevated male body mass influences success after assisted reproductive technologies
Retrospective study of 290 cycles.
Male body mass index greater than 25.0 kg/m2 was associated with significantly lower clinical pregnancy (53.2% vs. 33.6%). Multivariable logistic regression indicated that the likelihood of clinical pregnancy was decreased if the male partner was overweight after in vitro fertilization but not after intracytoplasmic sperm injection (odds ratios: 0.21 [0.07–0.69] vs. 0.75 [0.38–1.49], respectively) after adjustment for number of embryos transferred, sperm concentration, female age and body mass.
In this cohort, overweight status of the male partner was independently associated with decreased likelihood of clinical pregnancy after in vitro fertilization but not after intracytoplasmic sperm injection. A detrimental impact of higher male body mass was observed after adjusting for sperm concentration, suggesting that intracytoplasmic sperm injection may overcome some obesity related impairment of sperm-egg interaction.
KeywordsMale obesity In vitro fertilization IVF/ICSI outcome Assisted reproduction
Supported in part by K24 HD 41978 (NS)
- 5.Obesity and reproduction: an educational bulletin. Fertil Steril 2008;90(5 Suppl):S21–S9.Google Scholar
- 7.Polotsky AJ, Hailpern SM, Skurnick JH, Lo JC, Sternfeld B, Santoro N. Association of adolescent obesity and lifetime nulliparity-The Study of Women's Health Across the Nation (SWAN). Fertil Steril 2009.Google Scholar
- 15.Hofny ER, Ali ME, Abdel-Hafez HZ, El-Dien Kamal E, Mohamed EE, Abd El-Azeem HG et al. Semen parameters and hormonal profile in obese fertile and infertile males. Fertil Steril 2009.Google Scholar
- 18.Chavarro JE, Toth TL, Wright DL, Meeker JD, Hauser R. Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic. Fertil Steril 2009.Google Scholar
- 20.Obesity: Preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser. 2000;894:i–xii, 1–253.Google Scholar
- 38.Smajdor A. Should IVF guidelines be relaxed in the UK? Expert Rev Obstet & Gynecol. 2009;4:501–8.Google Scholar