Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

  • Paulo Marcelo Perin
  • Mariangela Maluf
  • Carlos Eduardo Czeresnia
  • Daniela Aparecida Nicolosi Foltran Januário
  • Paulo Hilário Nascimento Saldiva
Assisted reproduction



To assess the potential effects of short-term exposure to particulate air pollution during follicular phase on clinical, laboratory, and pregnancy outcomes of women undergoing IVF/ET.


Retrospective cohort study of 400 first IVF/ET cycles of women exposed to ambient particulate matter during follicular phase. Particulate matter (PM) was categorized into quartiles (Q1: ≤30.48 µg/m3, Q2: 30.49–42.00 µg/m3, Q3: 42.01–56.72 µg/m3, and Q4: >56.72 µg/m3).


Clinical, laboratory, or treatment variables were not affected by follicular phase PM exposure periods. Women exposed to Q4 period during the follicular phase of conception cycles had a higher risk of miscarriage (odds ratio, 5.05; 95% confidence interval: 1.04–25.51) when compared to women exposed to Q1–3 periods.


Our results show an association between brief exposure to high levels of ambient PM during the preconceptional period and early pregnancy loss, although no effect of this exposure on clinical, laboratory, and treatment outcomes was observed.


In vitro fertilization Particulate air pollution Embryo development Implantation Miscarriage 


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Paulo Marcelo Perin
    • 1
    • 3
  • Mariangela Maluf
    • 1
    • 3
  • Carlos Eduardo Czeresnia
    • 3
    • 4
  • Daniela Aparecida Nicolosi Foltran Januário
    • 2
    • 3
  • Paulo Hilário Nascimento Saldiva
    • 1
  1. 1.Department of Pathology, School of MedicineUniversity of São PauloSão PauloBrazil
  2. 2.Department of Experimental Physiopathology, School of MedicineUniversity of São PauloSão PauloBrazil
  3. 3.Division of Reproductive MedicineCEERH—Specialized Center for Human ReproductionSão PauloBrazil
  4. 4.Division of Reproductive MedicineCélula MaterSão PauloBrazil

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