IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: a systematic review and meta-analysis

  • Miguel A. ChecaEmail author
  • Pablo Alonso-Coello
  • Ivan Solà
  • Ana Robles
  • Ramón Carreras
  • Juan Balasch



To assess the efficacy of preimplantation genetic screening to increase ongoing pregnancy rates in couples without known genetic disorders.


Systematic review and meta-analysis of randomized controlled trials. Two reviewers independently determined study eligibility and extracted data.


Ten randomized trials (1,512 women) were included. The quality of evidence was moderate. Meta-analyses using a random-effects model suggest that PGS has a lower rate of ongoing pregnancies (risk ratio=0.73, 95% confidence interval 0.62–0.87) and a lower rate of live births (risk ratio=0.76, 95% confidence interval 0.64–0.91) than standard in vitro fertilization/intracytoplasmic sperm injection.


In women with poor prognosis or in general in vitro fertilization program, in vitro fertilization/intracytoplasmic sperm injection with preimplantation genetic screening for aneuploidy does not increase but instead was associated with lower rates of ongoing pregnancies and live births. The use of preimplantation genetic screening in daily practice does not appear to be justified.


Meta-analysis Preimplantation genetic screening Aneuploidy IVF/ICSI Advanced maternal age Recurrent pregnancy loss Repeated IVF failure 



We thank Marta Pulido, MD; for editing the manuscript and editorial assistance.

Conflict of interest


Financial support



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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Miguel A. Checa
    • 1
    Email author
  • Pablo Alonso-Coello
    • 2
    • 3
  • Ivan Solà
    • 2
  • Ana Robles
    • 1
  • Ramón Carreras
    • 1
  • Juan Balasch
    • 4
  1. 1.Department of Obstetrics and Gynecology, Hospital Universitari del MarAutonomous University of BarcelonaBarcelonaSpain
  2. 2.Centro Cochrane Iberoamericano, Servicio de Epidemiología Clínica y Salud Pública, Hospital de la Santa Creu i Sant PauAutonomous University of BarcelonaBarcelonaSpain
  3. 3.CIBER de Epidemiología y Salud Pública (CIBERESP)BarcelonaSpain
  4. 4.Institut Clínic of Gynecology, Obstetrics and Neonatology, Faculty of Medicine-University of BarcelonaHospital Clínic-Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)BarcelonaSpain

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