Human choriogonadotropin prior to controlled ovarian stimulation and in vitro fertilization improves implantation, and pregnancy rates

  • Eduardo L. Motta
  • Gary D. Smith
  • Paulo C. Serafini
  • Marcio Coslovsky
  • Pericles Hassun
  • Andre M. Rocha
  • Isaac YadidEmail author



Our purpose was to retrospectively compare controlled ovarian stimulation(COH) in IVF cycles with administration of hCG on the day of menses (D1-hCG) with women not receiving hCG at day 1 of menses (Control).


Data on maternal age, endocrine profile, amount of rFSH required, embryo characteristics, implantation and pregnancy rates were recorded for comparison between D1-hCG (n = 36) and Control (n = 64).


Dose of rFSH required to accomplish COH was significantly lower in D1-hCG. Following ICSI, more top-quality embryos were available for transfer per patient in the D1-hCG and biochemical pregnancy rates per transfer were significantly higher in the D1-hCG. Significantly higher implantation and on-going pregnancy rates per embryo transfer were observed in D1-hCG (64%) compared to Control (41%).


Administration of D1-hCG prior to COH reduces rFSH use and enhances oocyte developmental competence to obtain top quality embryos, and improves implantation and on-going pregnancy rates. At present it is not clear if the benefit is related to producing an embryo that more likely to implant or a more receptive uterus, or merely fortuitous and related to the relatively small power of the study.


Human choriogonadotropin Controlled ovarian hyperstimulation In vitro fertilization Oocyte developmental competence 



The authors would like to express appreciation to Claudia Vieira, Beto Jalegretti, Joyce Fioravanti, and Lia Rossi for technical and editorial input and comments. Additionally, the authors thank Dr. Carrie Cosola-Smith and Jeni Chapman for editorial comments.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Eduardo L. Motta
    • 1
    • 2
    • 4
  • Gary D. Smith
    • 5
    • 6
    • 7
    • 8
  • Paulo C. Serafini
    • 1
    • 2
    • 3
  • Marcio Coslovsky
    • 1
  • Pericles Hassun
    • 9
  • Andre M. Rocha
    • 1
    • 2
  • Isaac Yadid
    • 1
    Email author
  1. 1.Huntington Center for Reproductive Medicine of BrazilRio de JaneiroBrazil
  2. 2.Huntington Medicina Reprodutiva, Av. República do Líbano529-São PauloBrazil
  3. 3.Departamento de Ginecologia, Faculdade de MedicinaUniversidade de São Paulo255 São PauloBrazil
  4. 4.Departamento de GinecologiaUniversidade Federal de São Paulo740 São PauloBrazil
  5. 5.Department of Obstetrics and GynecologyUniversity of MichiganAnn ArborUSA
  6. 6.Department of UrologyUniversity of MichiganAnn ArborUSA
  7. 7.Department of PhysiologyUniversity of MichiganAnn ArborUSA
  8. 8.Reproductive Science ProgramUniversity of MichiganAnn ArborUSA
  9. 9.Genesis Genetics BrasilSão PauloBrazil

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