Previous tubal ectopic pregnancy raises the incidence of repeated ectopic pregnancies in In Vitro fertilization-embryo transfer patients

  • Monika Weigert
  • Diego Gruber
  • Elisabeth Pernicka
  • Peter Bauer
  • Wilfried Feichtinger



To investigate the incidence of Tubal Ectopic Pregnancies (TEP) in IVF-ET patients with respect to the status of the fallopian tubes after a previous TEP.

Material and methods

This retrospective study compares patients undergoing 481 IVF-ET cycles after conservatively or surgically treated TEP(s) with a Control Group (idiopathic or male factor for IVF-ET indication). Medical reports of surgery and/or hysterosalpingograms prior to the IVF cycles classified the status of the fallopian tubes.


12 TEPs (8.95%/Pregnancies (PR)) occurred in the Study Group. In the Control Group one TEP (0.75%/PR; p < 0.001) was found. Smoking increased the probability of TEPs (p = 0.0028) and of pathological pregnancies (abortion, biochemical and ectopic PR; (p = 0.0411)). For statistic evolution logistic regression (PROC GENMOD) and a repeated measure model were applied.


Women with a previous TEP should be informed about the significantly increased risk for a further TEP in IVF-ET treatment, especially if they are smoking.


Ectopic pregnancy  IVF-ET Assisted reproduction Tubal surgery Pregnancy rate 


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Monika Weigert
    • 1
    • 3
  • Diego Gruber
    • 2
  • Elisabeth Pernicka
    • 2
  • Peter Bauer
    • 2
  • Wilfried Feichtinger
    • 1
  1. 1.WunschbabyzentrumViennaAustria
  2. 2.Section of Medical Statistics, Core Unit for Medical Statistics and InformaticsMedical University of ViennaViennaAustria
  3. 3.ViennaAustria

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