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Journal of Assisted Reproduction and Genetics

, Volume 25, Issue 8, pp 389–394 | Cite as

CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women

  • Yi Ye
  • Xiao Cheng
  • Hai-Bo Luo
  • Li Liu
  • Ying-Bi Li
  • Yi-Ping HouEmail author
GENETICS

Abstract

Purpose

The aim of the study was to evaluate the association of CYP1A1 and CYP1B1 polymorphisms with uterine leiomyoma in Chinese women.

Methods

We investigated 100 women with clinically diagnosed uterine leiomyoma and 110 healthy normal subjects from Chinese women. The genetic distribution of two CYP1A1 polymorphisms at MspI, Ile462Val and four CYP1B1 polymorphisms at Arg48Gly, Ala119Ser, Leu432Val, Asp449Asp were analyzed by polymerase chain reaction–restriction fragment length polymorphism and DNA sequencing method.

Results

All the SNPs showed polymorphisms in Chinese women. The genotype A/G and the allele G on Ile462Val was significantly different between uterine leiomyoma patients and controls (P < 0.05).

Conclusion

These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk of uterine leiomyomas in Chinese women.

Keywords

CYP1A1 CYP1B1 Uterine leiomyoma Genetic polymorphism 

Notes

Acknowledgments

This work has been supported by Neijiang First People’s Hospital.

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Yi Ye
    • 1
  • Xiao Cheng
    • 1
  • Hai-Bo Luo
    • 1
  • Li Liu
    • 2
  • Ying-Bi Li
    • 1
  • Yi-Ping Hou
    • 1
    Email author
  1. 1.Department of Forensic Biology, West China School of Preclinical and Forensic MedicineSichuan UniversityChengduChina
  2. 2.Institute of Forensic MedicineZunyi Medical CollegeZunyiChina

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