Stress and reproductive failure: past notions, present insights and future directions

  • Katrina NakamuraEmail author
  • Sam Sheps
  • Petra Clara Arck



Maternal stress perception is frequently alleged as a cause of infertility, miscarriages, late pregnancy complications or impaired fetal development. The purpose of the present review is to critically assess the biological and epidemiological evidence that considers the plausibility of a stress link to human reproductive failure.


All epidemiological studies published between 1980 and 2007 that tested the link between stress exposure and impaired reproductive success in humans were identified. Study outcomes were evaluated on the basis of how associations were predicted, tested and integrated with theories of etiology arising from recent scientific developments in the basic sciences. Further, published evidence arising from basic science research has been assessed in order to provide a mechanistic concept and biological evidence for the link between stress perception and reproductive success.


Biological evidence points to an immune–endocrine disequilibrium in response to stress and describes a hierarchy of biological mediators involved in a stress trigger to reproductive failure. Epidemiological evidence presents positive correlations between various pregnancy failure outcomes with pre-conception negative life events and elevated daily urinary cortisol. Strikingly, a relatively new conceptual approach integrating the two strands of evidence suggests the programming of stress susceptibility in mother and fetus via a so-called pregnancy stress syndrome.


An increasing specificity of knowledge is available about the types and impact of biological and social pathways involved in maternal stress responses. The present evidence is sufficient to warrant a reconsideration of conventional views on the etiology of reproductive failure. Physicians and patients will benefit from the adaptation of this integrated evidence to daily clinical practice.


Stress Epidemiology Pregnancy complications Infertility Spontaneous abortion 



Valuable assistance to KLK was provided by Dr. James Tansey, Assistant Professor and Chair of Business Ethics at the Sauder School of Business, UBC. The authors are grateful for the support provided by Mirjam Ruecke and Ronny Schwierzinski in performing a prospective cohort trial.


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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Katrina Nakamura
    • 1
    Email author
  • Sam Sheps
    • 2
    • 3
  • Petra Clara Arck
    • 4
    • 5
  1. 1.Interdisciplinary Studies Graduate ProgramUniversity of British ColumbiaVancouverCanada
  2. 2.Department of Health Care and EpidemiologyUniversity of British ColumbiaVancouverCanada
  3. 3.Western Regional Training Center for Health and Policy ResearchUniversity of British ColumbiaVancouverCanada
  4. 4.Charité University MedicineBerlinGermany
  5. 5.Brain Body InstituteMcMaster UniversityHamiltonCanada

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