Journal of Assisted Reproduction and Genetics

, Volume 23, Issue 4, pp 161–169 | Cite as

Power Doppler ultrasound assessment of follicular vascularity in the early follicular phase and its relationship with outcome of in vitro fertilization

  • S. M. Shrestha
  • M. F. Costello
  • P. Sjoblom
  • G. McNally
  • M. Bennett
  • S. J. Steigrad
  • G. J. Hughes
Assisted Reproduction

Objective: To determine whether ovarian perifollicular blood flow (PFBF) in the early follicular phase (EFP) was associated with treatment outcome.

Design: Retrospective longitudinal cohort study.

Setting: Tertiary referral centre/university hospital.

Patients: Thirty-four women underwent 37 IVF cycles, which resulted in 35 embryo transfers.

Interventions: Serial transvaginal scans using power Doppler ultrasound during the follicular phase. Ovarian PFBF of follicles ≥5 mm was subjectively assessed using a modified grading system (grades 0–4).

Main outcome measures: Ovarian PFBF and pregnancy.

Results: Treatment cycles were retrospectively divided into two groups: Group 1 (n=20) had cycles with at least one small (5–10 mm) or medium (11–14 mm) size follicle(s) of high grade (2–4) PFBF on cycle day 5 or 6 or 7; and Group 2 (n=17), had cycles that did not. Group 1 had a significantly higher proportion of high grade large follicles in the late follicular phase (35% vs. 21%) (OR 2.0; 95% CI 1.1–3.7) and higher clinical pregnancy rate (47% vs. 12%) (OR 6.3; CI 1.1–35.7) compared to Group 2.

Conclusion: High grade ovarian PFBF in the EFP during IVF is associated with both high grade PFBF in the late follicular phase and a higher clinical pregnancy rate.

KEY WORDS:

Early follicular phase IVF perifollicular vascularity power Doppler ultrasound pregnancy rate 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • S. M. Shrestha
    • 1
    • 2
  • M. F. Costello
    • 1
    • 2
  • P. Sjoblom
    • 1
    • 2
    • 4
  • G. McNally
    • 3
  • M. Bennett
    • 1
  • S. J. Steigrad
    • 2
  • G. J. Hughes
    • 1
    • 2
  1. 1.School of Women's and Children's HealthUniversity of New South WalesSydneyAustralia
  2. 2.Department of Reproductive Medicine and IVFMaroubraAustralia
  3. 3.Department of Medical ImagingRoyal Hospital for WomenRandwickAustralia
  4. 4.Fertility Centre Scandinavia StockholmStockholmSweden

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