Purpose: To predict the ongoing likelihood of natural conception, when a couple has ceased to try to conceive by assisted conception.
Methods: A postal questionnaire survey obtained information on further attempts to conceive and have a baby, either without treatment or by treatment elsewhere.
Results: From a response rate of 44%, there were 116 couples who fulfilled the study criteria. The data presented are based on this group. The overall likelihood of conception was 18%. Cumulative results were analysed up to 3 years following treatment. Univariate analysis showed that likelihood of conception was affected by infertility diagnosis (p = 0.024), woman's age (> 38 years; p < 0.005) (negatively) and duration of infertility (< 3 years; p < 0.005) (positively), while primary infertility did not. Effects of diagnosis and infertility duration were confirmed by multivariable analysis, controlling for age and primary infertility. These latter variables had no independent effect.
Conclusion: The likelihood of natural conception following IVF treatment was determined by duration of infertility and diagnosis; tubal disease in particular was associated with a very poor likelihood of natural conception.
Assisted conception diagnostic classification failure to conceive fertility likelihood of natural conception
Evers JL, de Haas HW, Land JA, Dumoulin JC, Dunselman GA: Treatment-independent pregnancy rate in patients with severe reproductive disorders. Hum Reprod 1998;13(5):1206–1209CrossRefPubMedGoogle Scholar
Alam V, Solis F, Zegers-Hochschild F, Balmaceda JP: Spontaneous pregnancy after ART cycles: Follow up of 927 cycles. In Abstracts of the 14th Annual Meeting of the ESHRE, Goteborg, 1998; p. 70Google Scholar
Kupka MS, Dorn C, Richter O, van der Ven HH, Krebs D: Prognostic factors for treatment-independent pregnancies in assisted reproduction. In Abstracts of the 15th Annual Meeting of the ESHRE, Tours, France, 1999; pp. 316–317Google Scholar
Roh SI, Awadalla SG, Friedman CI, Park JM, Chin N, Dodds WG et al.: In vitro fertilization and embryo transfer: Treatment-dependent versus -independent pregnancies. Fertil Steril 1987;48(6):982–986PubMedGoogle Scholar
Shimizu Y, Kodama H, Fukuda J, Murata M, Kumagai J, Tanaka T: Spontaneous conception after the birth of infants conceived through in vitro fertilization treatment. Fertil Steril 1999;71(1):35–39CrossRefPubMedGoogle Scholar
Hull MG, Glazener CM, Kelly NJ, Conway DI, Foster PA, Hinton RA et al.: Population study of causes, treatment and outcome of infertility. BMJ 1985;291:1693–1697PubMedGoogle Scholar
Collins JA, Burrows EA, Willan AR: The prognosis for live birth among untreated infertile couples. Fertil Steril 1995;64(1):22–28PubMedGoogle Scholar
Snick HKA, Snick TS, Evers JLH, Collins JA: The spontaneous pregnancy prognosis in untreated subfertile couples: The Walcheren primary care study. Hum Reprod 1997;12(7):1582–1588CrossRefPubMedGoogle Scholar
Vardon D, Burban C, Collomb J, Stolla V, Erny R: Spontaneous pregnancies in couples after failed or successful in vitro fertilization. J Gynecol Obstet Biol Reprod (Paris) 1995;24(8):811–815Google Scholar
Hull MG, Eddowes HA, Fahy U, Abuzeid MI, Mills MS, Cahill DJ et al.: Expectations of assisted conception for infertility. BMJ 1992;304(6840):1465–1469PubMedCrossRefGoogle Scholar
Olivennes F, Kerbrat V, Rufat P, Blanchet V, Fanchin R, Frydman R: Follow-up of a cohort of 422 children aged 6 to 13 years conceived by in vitro fertilization. Fertil Steril 1997;67(2):284–289CrossRefPubMedGoogle Scholar
Gleicher N, VanderLaan B, Pratt D, Karande V: Background pregnancy rates in an infertile population. Hum Reprod 1996;11(5):1011–1012PubMedGoogle Scholar
Hull MG, Fleming CF, Hughes AO, McDermott A: The age-related decline in female fecundity: A quantitative controlled study of implanting capacity and survival of individual embryos after in vitro fertilization. Fertil Steril 1996;65(4):783–790PubMedGoogle Scholar
Ziebe S, Loft A, Petersen JH, Andersen AG, Lindenberg S, Petersen K et al.: Embryo quality and developmental potential is compromised by age. Acta Obstet Gynecol Scand 2001;80(2):169–174CrossRefPubMedGoogle Scholar
Akande VA, Fleming CF, Hunt LP, Keay SD, Jenkins JM: Biological versus chronological ageing of oocytes, distinguishable by raised FSH levels in relation to the success of IVF treatment. Hum Reprod 2002;17(8):2003–2008CrossRefPubMedGoogle Scholar